STRUCTURAL AND FUNCTIONAL RECOVERY OF AUDITORY HAIR CELLS IN ZEBRAFISH

斑马鱼听觉毛细胞的结构和功能恢复

• 批准号: 7610396
• 负责人: MICHAEL SMITH
• 金额: $ 9.18万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610396
• 关键词: Apoptosis; Auditory; Birds; Cell physiology; Computer Retrieval of Information on Scientific Projects Database; Epithelium; Exhibits; Fishes; Funding; Genes; Goldfish; Grant; Hair Cells; Hearing; Institution; Knowledge; Lead; Mammals; Mediating; Natural regeneration; Noise; Recovery; Recovery of Function; Research; Research Personnel; Resources; Sensory; Signal Transduction; Source; United States National Institutes of Health; Vertebrates; Zebrafish; cell growth; cell injury; cellular transduction; hearing impairment; relating to nervous system; transdifferentiation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Auditory hair cells are the sensory cells that transduce acoustical signals into neural ones in vertebrates, thus providing the ability to hear. In mammals, when these terminally-differentiated cells are damaged or lost, the result is permanent loss of hearing since lost mammalian hair cells do not regenerate. In fish and birds, damaged auditory sensory epithelia have the capability of regenerating new hair cells, resulting in recovery of hearing. Recent studies show that goldfish exhibit both structural (hair cells) and functional (hearing) recovery following noise exposure. To fully understand what normal cellular processes lead to regeneration in fishes, knowledge of how specific genes mediate hair cell growth (proliferation and transdifferentiation) and apoptosis is essential.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 听觉毛细胞是脊椎动物的感觉细胞，负责将声音信号传递到神经元，从而提供听觉能力。 在哺乳动物中，当这些终末分化的细胞受损或丢失时，结果是永久性听力损失，因为丢失的哺乳动物毛细胞不能再生。在鱼类和鸟类中，受损的听觉上皮细胞具有再生新毛细胞的能力，从而恢复听力。最近的研究表明，金鱼在噪声暴露后表现出结构（毛细胞）和功能（听力）的恢复。为了充分了解正常的细胞过程导致鱼类再生，特定基因如何介导毛细胞生长（增殖和转分化）和凋亡的知识是必不可少的。