STRUCTURAL AND FUNCTIONAL RECOVERY OF AUDITORY HAIR CELLS IN ZEBRAFISH

斑马鱼听觉毛细胞的结构和功能恢复

• 批准号: 7960116
• 负责人: MICHAEL SMITH
• 金额: $ 9.95万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-22 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960116
• 关键词: Apoptosis; Auditory; Biomedical Research; Birds; Cell physiology; Computer Retrieval of Information on Scientific Projects Database; Epithelium; Exhibits; Fishes; Funding; Genes; Goldfish; Grant; Hair Cells; Hearing; Institution; Knowledge; Lead; Mammals; Mediating; Natural regeneration; Noise; Recovery; Recovery of Function; Research; Research Personnel; Resources; Sensory; Signal Transduction; Source; United States National Institutes of Health; Vertebrates; Zebrafish; cell growth; cell injury; cellular transduction; hearing impairment; relating to nervous system; transdifferentiation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Auditory hair cells are the sensory cells that transduce acoustical signals into neural ones in vertebrates, thus providing the ability to hear. In mammals, when these terminally-differentiated cells are damaged or lost, the result is permanent loss of hearing since lost mammalian hair cells do not regenerate. In fish and birds, damaged auditory sensory epithelia have the capability of regenerating new hair cells, resulting in recovery of hearing. Recent studies show that goldfish exhibit both structural (hair cells) and functional (hearing) recovery following noise exposure. To fully understand what normal cellular processes lead to regeneration in fishes, knowledge of how specific genes mediate hair cell growth (proliferation and transdifferentiation) and apoptosis is essential.

这个子项目是众多研究子项目之一