SLEEP DISTURBANCE AND PAIN SENSITIVITY IN CHRONIC PAIN

这个子项目是众多研究子项目之一

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Sleep disturbance is one of the most disabling correlates of pain affecting between 50-80% of the 50 million adults suffering from chronic pain. Epidemiologic research supports the contention that sleep disturbance substantially increases risk for serious medical and psychiatric morbidities, but sleep research in chronic pain is limited. Research in healthy subjects suggests that sleep and pain are reciprocally linked, such that pain disrupts sleep and sleep disruption exacerbates pain. This relationship has been inadequately studied in clinical populations and empirical approaches to treatment are lacking. These investigators propose a longitudinal study of patients with chronic myofascial pain associated with temporomandibular joint disorder (TMD). The aims of this study are to 1) characterize sleep disturbances associated with TMD 2) determine whether the diagnosis of insomnia and or sleep microstructure abnormalities are associated with increased mechanical masticatory muscle pain, and 3) to evaluate whether baseline sleep continuity and/or NREM sleep microstructure profiles predict the subsequent course of TMD pain.