STRUCTURAL AND FUNCTIONAL RECOVERY OF AUDITORY HAIR CELLS IN ZEBRAFISH

斑马鱼听觉毛细胞的结构和功能恢复

• 批准号: 7720140
• 负责人: MICHAEL SMITH
• 金额: $ 9.89万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720140
• 关键词: Apoptosis; Auditory; Birds; Cell physiology; Computer Retrieval of Information on Scientific Projects Database; Epithelium; Exhibits; Fishes; Funding; Genes; Goldfish; Grant; Hair Cells; Hearing; Institution; Knowledge; Lead; Mammals; Mediating; Natural regeneration; Noise; Recovery; Recovery of Function; Research; Research Personnel; Resources; Sensory; Signal Transduction; Source; United States National Institutes of Health; Vertebrates; Zebrafish; cell growth; cell injury; cellular transduction; hearing impairment; relating to nervous system; transdifferentiation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Auditory hair cells are the sensory cells that transduce acoustical signals into neural ones in vertebrates, thus providing the ability to hear. In mammals, when these terminally-differentiated cells are damaged or lost, the result is permanent loss of hearing since lost mammalian hair cells do not regenerate. In fish and birds, damaged auditory sensory epithelia have the capability of regenerating new hair cells, resulting in recovery of hearing. Recent studies show that goldfish exhibit both structural (hair cells) and functional (hearing) recovery following noise exposure. To fully understand what normal cellular processes lead to regeneration in fishes, knowledge of how specific genes mediate hair cell growth (proliferation and transdifferentiation) and apoptosis is essential.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 听觉毛细胞是脊椎动物将声音信号转化为神经信号的感觉细胞，从而提供听力能力。在哺乳动物中，当这些终末分化细胞受损或丢失时，结果是永久性的听力丧失，因为丢失的哺乳动物毛细胞不能再生。在鱼类和鸟类中，受损的听觉感觉上皮具有再生新毛细胞的能力，从而恢复听力。最近的研究表明，金鱼在噪声暴露后表现出结构(毛细胞)和功能(听力)恢复。为了充分了解什么是正常的细胞过程导致鱼类再生，了解特定基因如何调节毛细胞生长(增殖和转分化)和凋亡是必不可少的。