MARKERS OF RISK FOR NICOTINE DEPENDENCE IN YOUNGSTERS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。吸烟通常从青春期开始，并与重大的社会经济和心理社会负担有关。有证据表明，抑郁症会增加吸烟的风险，反之亦然。已观察到HPA调节的改变与抑郁性疾病和ND&GT有关；基于这一证据，推测HPA活性的改变可能是抑郁症患者以及非抑郁者增加ND风险的中介力量。在关注HPA轴在ND发生发展中的作用时，重要的是要考虑尼古丁对HPA系统的相互影响。由于开始吸烟和定期使用尼古丁发生在青春期，这一发育期提供了一个独特的机会来评估与ND相关的潜在机制，而不会出现由于长期吸烟而可能在成年人身上发生的许多潜在的混杂变量。具体目的：1)研究下丘脑-垂体-肾上腺(HPA)系统的失调与吸烟或进展为尼古丁依赖(ND)的风险之间的关系。2)评估HPA失调与吸烟引发或发展成ND的风险之间的关系是否受抑郁疾病的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cigarette smoking frequently begins in adolescence and is associated with significant socioeconomic and psychosocial burden. There is evidence that depression increases the risk for smoking and vice versa. Alterations in HPA regulation have been observed in association with both depressive illness and ND> Based on this evidence, it is hypothesized that altered HPA activity may be the mediating force in increasing the risk for ND in depressed individuals, and possibly in non-depressed persons as well. In attenpting to establish the role of HPA axis on the development of ND, it is important to consider that nicotine has a reciprocal influence on the HPA system. Because initiation of cigarette smoking and progression to regular nicotine use occurs during adolescence, this developmental period offers a unique opportunity to assess the underlying mechanisms associated with ND without many of the potentially confounding variables that might occur in adults as a result of chronic smoking. Specific Aims: 1) To examine the relationship between dysregulation in the hypothalamic-pituitary-adrenal (HPA) system and risk for initiation of cigarette smoking or progression to nicotine dependence (ND). 2) To assess whether the association between HPA dysregulation and risk for smoking initiation or development of ND is influenced by depressive illness.