HANGOVER, CONGENERS, SLEEP, AND OCCUPATIONAL PERFORMANCE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们的研究建议通过解决几个问题来增加对大量饮酒的残余影响的理解。我们将测试几个假设的机制，大量饮酒影响第二天的表现。使用安慰剂对照随机试验，我们将在测试受试者的神经行为表现的前一天晚上给受试者服用安慰剂或高或低同源酒精饮料（至0.10 g %BAC的水平），这些神经行为表现通过使用基于计算机的神经行为评估系统（内斯3）的经验证的认知障碍测试进行测量。此外，我们将使用基于计算机的心理警觉测试（PVT）测试参与者因疲劳而造成的损伤。我们将监测参与者的睡眠以评估睡眠障碍;收集给药后第二天早上宿醉症状的信息;并收集参与者饮酒问题家族史的数据。我们将检验以下假设：（1）相对于安慰剂，大量饮酒会降低第二天的认知功能，如通过NES 3测量的;（2）相对于安慰剂，大量饮酒会降低第二天的反应时间，如通过PVT测量的; NES 3和PVT都将全部或部分由睡眠质量介导;（3）高同类酒精饮料将比低同类饮料在更大程度上影响表现，并且这种关系将由宿醉症状的严重程度介导;和（4）相对于家族史阴性的参与者，酒精问题家族史阳性的参与者中大量饮酒对第二天表现的残留影响将减弱。研究程序将进行两次，间隔一周，转换个体的给药状态。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our study proposes to increase understanding of the residual effects of heavy drinking by addressing several questions. We will test several hypotheses regarding the mechanism by which heavy drinking effects next-day performance. Using a placebo-controlled randomized trial, we will dose participants with placebo or with a high or low congener alcoholic beverage (to a level of 0.10 g% BAC) the night before testing their neurobehavioral performance as measured by validated tests of cognitive impairment using the computer based Neurobehavioral Evaluation System (NES 3). In addition, we will test participant impairment due to fatigue using computer based Psychomotor Vigilence Testing (PVT). We will monitor participants' sleep to assess sleep disturbance; collect information on hangover symptoms the morning after dosing; and collect data on participants' family history of drinking problems. We will test the following hypotheses: (1) relative to placebo, heavy drinking will degrade next-day cognitive functioning as measured by the NES3 (2) relative to placebo, heavy drinking will degrade next-day reaction time as measured by the PVT; and both the NES3 and the PVT will be mediated in full or in part by quality of sleep; (3) a high congener alcoholic beverage will affect performance to a greater degree than a low congener beverage and this relationship will be mediated by severity of hangover symptoms; and (4) the residual effects of heavy drinking on next-day performance will be attenuated among participants positive for a family history of alcohol problems, relative to family-history-negative participants. The study procedure will be conducted twice with one week in between, switching the individuals' dosing status.