HANGOVER, CONGENERS, SLEEP, AND OCCUPATIONAL PERFORMANCE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们的研究建议通过解决几个问题来增加对大量饮酒的后遗症的了解。我们将测试几个关于大量饮酒影响第二天表现的机制的假说。采用安慰剂对照的随机试验，我们将在参与者使用计算机神经行为评估系统(NES 3)对认知障碍进行验证测试的前一天晚上，给参与者服用安慰剂或高或低同类酒精饮料(水平为0.10g%BAC)，以测试他们的神经行为表现。此外，我们将使用基于计算机的精神运动警觉测试(PVT)来测试参与者因疲劳而造成的损害。我们将监测参与者的睡眠以评估睡眠障碍；收集服药后第二天早上宿醉症状的信息；并收集参与者饮酒问题家族史的数据。我们将检验以下假设：(1)相对于安慰剂，大量饮酒会降低NES3测量的第二天认知功能；(2)相对于安慰剂，大量饮酒会降低PVT测量的第二天反应时；NES3和PVT都将完全或部分通过睡眠质量来调节；(3)高同种酒精饮料对表现的影响比低同种酒精饮料更大，这种关系将通过宿醉症状的严重程度来调节；(4)与家族史阴性的参与者相比，有酗酒家族史的参与者在第二天的表现中大量饮酒的残余影响会减弱。研究程序将进行两次，其间一周，切换个人的服药状态。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our study proposes to increase understanding of the residual effects of heavy drinking by addressing several questions. We will test several hypotheses regarding the mechanism by which heavy drinking effects next-day performance. Using a placebo-controlled randomized trial, we will dose participants with placebo or with a high or low congener alcoholic beverage (to a level of 0.10 g% BAC) the night before testing their neurobehavioral performance as measured by validated tests of cognitive impairment using the computer based Neurobehavioral Evaluation System (NES 3). In addition, we will test participant impairment due to fatigue using computer based Psychomotor Vigilence Testing (PVT). We will monitor participants' sleep to assess sleep disturbance; collect information on hangover symptoms the morning after dosing; and collect data on participants' family history of drinking problems. We will test the following hypotheses: (1) relative to placebo, heavy drinking will degrade next-day cognitive functioning as measured by the NES3 (2) relative to placebo, heavy drinking will degrade next-day reaction time as measured by the PVT; and both the NES3 and the PVT will be mediated in full or in part by quality of sleep; (3) a high congener alcoholic beverage will affect performance to a greater degree than a low congener beverage and this relationship will be mediated by severity of hangover symptoms; and (4) the residual effects of heavy drinking on next-day performance will be attenuated among participants positive for a family history of alcohol problems, relative to family-history-negative participants. The study procedure will be conducted twice with one week in between, switching the individuals' dosing status.