HANGOVER, CONGENERS, SLEEP, AND OCCUPATIONAL PERFORMANCE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们的研究建议通过解决几个问题来增加对大量饮酒残留影响的理解。我们将测试关于大量饮酒影响第二天表现的机制的几个假设。采用安慰剂对照的随机试验，我们将在测试参与者神经行为表现的前一晚给他们服用安慰剂或高或低同系物酒精饮料（浓度为BAC的0.10 g%），这些神经行为表现是通过基于计算机的神经行为评估系统（NES 3）进行的有效的认知障碍测试来测量的。此外，我们将使用基于计算机的精神运动警觉性测试（PVT）来测试参与者因疲劳而造成的损伤。我们将监测参与者的睡眠以评估睡眠障碍；在服药后的早晨收集宿醉症状的信息；并收集参与者的饮酒家族史数据。我们将检验以下假设：(1)相对于安慰剂，大量饮酒会降低第二天的认知功能（NES3测量）；(2)相对于安慰剂，大量饮酒会降低第二天的反应时间（PVT测量）；NES3和PVT都将全部或部分由睡眠质量调节；(3)同系度高的酒精饮料比同系度低的酒精饮料对运动表现的影响更大，且这种关系受宿醉症状严重程度的调节；(4)与没有酗酒家族史的参与者相比，有酗酒家族史的参与者对第二天表现的残余影响会减弱。研究过程将进行两次，间隔一周，切换个体的给药状态。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our study proposes to increase understanding of the residual effects of heavy drinking by addressing several questions. We will test several hypotheses regarding the mechanism by which heavy drinking effects next-day performance. Using a placebo-controlled randomized trial, we will dose participants with placebo or with a high or low congener alcoholic beverage (to a level of 0.10 g% BAC) the night before testing their neurobehavioral performance as measured by validated tests of cognitive impairment using the computer based Neurobehavioral Evaluation System (NES 3). In addition, we will test participant impairment due to fatigue using computer based Psychomotor Vigilence Testing (PVT). We will monitor participants' sleep to assess sleep disturbance; collect information on hangover symptoms the morning after dosing; and collect data on participants' family history of drinking problems. We will test the following hypotheses: (1) relative to placebo, heavy drinking will degrade next-day cognitive functioning as measured by the NES3 (2) relative to placebo, heavy drinking will degrade next-day reaction time as measured by the PVT; and both the NES3 and the PVT will be mediated in full or in part by quality of sleep; (3) a high congener alcoholic beverage will affect performance to a greater degree than a low congener beverage and this relationship will be mediated by severity of hangover symptoms; and (4) the residual effects of heavy drinking on next-day performance will be attenuated among participants positive for a family history of alcohol problems, relative to family-history-negative participants. The study procedure will be conducted twice with one week in between, switching the individuals' dosing status.