Acute and residual effects of beer vs. caffeinated beer on simulated driving

啤酒与含咖啡因啤酒对模拟驾驶的急性和残留影响

• 批准号: 7178427
• 负责人: Jonathan Howland
• 金额: $ 25万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2009-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7178427
• 关键词: alcoholic beverage consumption; alcoholic beverages; attention; behavioral /social science research tag; caffeine; clinical research; clinical trials; computer simulation; driving while intoxicated; human subject; injury prevention; neurotoxicology; occupational health /safety; psychomotor reaction time; questionnaires; self concept; transportation /recreation safety

Hingson and Howland (2002) estimated that 1,138 college students die from alcohol-related traffic crashes annually. An additional 307 college students die annually from alcohol-related non-traffic unintentional injuries and 500,000 college students annually sustain alcohol-related injuries (Hingson and Howland 2002). Caffeinated alcoholic beverages target young adults with the promise that the caffeine will counteract the sedating effects of alcohol and thus let the consumer remain alert and active longer, while continuing to drink. If young people erroneously believe that caffeine in beer will protect them from alcohol-related injury, then such beverages may increase mortality and morbidity in this population. Thus, it is important to have accurate information about the extent to which such beverages affect impairment both acutely and residually. Such information could correct misunderstandings young people have about the relative safety of caffeinated beer and thereby reduce injury. The study could have implications for safety-sensitive occupations as well. It is common for people to use caffeine to counteract the sedative effects of alcohol. If, however, the alcohol and caffeine interact to yield greater impairment in next-day performance, workers should be aware of this, particularly if their jobs have low tolerance for error. This study, to our knowledge, will be the first to compare the acute and residual effects of caffeinated and non-caffeinated beer on driving performance. Objectives: The aim of this study is to develop information about the acute and residual effects of a new product being targeted to young adults. It is important to understand the effects of caffeinated alcoholic beverages early on in the marketing campaign so that if they pose a greater threat to pubic health than traditional alcoholic beverages, (1) consumers can be educated and (2) policy-making can be informed with accurate information. We will compare the acute and residual effects on driving impairment of caffeinated and non-caffeinated beer to each other and to placebo when participants have received sufficient alcoholic beverage to attain a blood alcohol concentration (BAC) of .12 g%. Study Design: We will conduct a placebo-controlled trial using a 2 X 2 mixed-model study design. The within-subjects factor will be alcohol vs. placebo; the between-subjects factor will be caffeinated vs. noncaffeinated beer. Setting: The study will take place at the General Clinical Research Center at Boston Medical Center. Participants: We will recruit 144 students from Boston area Universities. Outcome Measures: Acute and residual driving impairment will be assessed using a driving simulator and an objective measure of sustained attention/reaction time, the Psychomotor Vioilance Test (PVT).

Hingson和Howland(2002)估计有1138名大学生死于与酒精有关的疾病 每年都会发生交通事故。每年另有307名大学生死于与酒精相关的非交通事故 意外伤害和每年500,000名大学生遭受与酒精有关的伤害(Hingson和 Howland 2002)。含咖啡因的酒精饮料以年轻人为目标，承诺咖啡因将 中和酒精的镇静作用，从而让消费者保持更长时间的警觉和活跃，而 继续喝酒。如果年轻人错误地认为啤酒中的咖啡因会保护他们免受与酒精有关的伤害 那么，这种饮料可能会增加这一人群的死亡率和发病率。因此，它是 重要的是要有关于这种饮料影响损害程度的准确信息 尖锐而残存的。这样的信息可以纠正年轻人对 相对安全的含咖啡因啤酒，从而减少伤害。这项研究可能会对安全敏感性产生影响 职业也是如此。人们使用咖啡因来抵消咖啡因的镇静作用是很常见的 酒精。然而，如果酒精和咖啡因相互作用，在第二天的表现中产生更大的损害， 工人们应该意识到这一点，特别是当他们的工作对错误的容忍度很低的时候。这项研究，对我们 知识，将是第一个比较含咖啡因和不含咖啡因啤酒的急性和残留影响的人 关于驾驶性能。 目的：这项研究的目的是了解一种新的药物的急性和残留效应 针对年轻人的产品。了解含咖啡因酒精的影响是很重要的。 在营销活动早期就饮用饮料，以便在对公众健康构成比 传统酒精饮料，(1)可以教育消费者，(2)可以为政策制定提供信息 准确的信息。我们将比较咖啡因对驾驶损害的急性和残余影响 当参与者喝了足够的酒精后，互相喝不含咖啡因的啤酒，并服用安慰剂 饮料的血液酒精浓度(BAC)必须达到0.12克%。 研究设计：我们将采用2×2混合模型研究设计进行安慰剂对照试验。这个 受试者内部因素将是酒精与安慰剂；受试者之间因素将是咖啡因与不含咖啡因 啤酒。 地点：这项研究将在波士顿医学中心的综合临床研究中心进行。 参与者：我们将从波士顿地区大学招收144名学生。 结果衡量：将使用驾驶模拟器评估急性和残余驾驶损害，并 持续注意力/反应时间的客观测量，精神运动暴力测试(PVT)。