GENETIC CORRELATES WITH PROPENSITY FOR HANGOVER: AN EXPLORATORY STUDY

遗传与宿醉倾向相关：一项探索性研究

• 批准号: 7606285
• 负责人: Jonathan Howland
• 金额: $ 0.17万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606285
• 关键词: Alcohol dehydrogenase; Candidate Disease Gene; Cells; Cheek structure; Computer Retrieval of Information on Scientific Projects Database; Consent; DNA analysis; Data; Data Analyses; Epithelial; Etiology; Funding; Genes; Genetic; Gossypium; Grant; Institution; Intoxication; Medical center; Occupational; Participant; Performance; Procedures; Protocols documentation; Purpose; Research; Research Personnel; Residual state; Resources; Risk; Sampling; Skin; Sleep; Source; Students; Swab; Testing; United States Department of Veterans Affairs; United States National Institutes of Health; parent project; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This genetics sub study proposes to collect a sample of cheek epithelial (skin) cells for the purpose of DNA analysis from the pool of study participants in protocols H-22722 (Hangover, Congener, Sleep and Occupational Performance) and H- 23064 (Residual Effects of Intoxication on Student Performance) who volunteer for this study. The objective of this analysis is to assess whether the propensity for hangover, may be moderated by genetic differences in the alcohol dehydrogenase gene (ADH). Genetics data combined with data from the parent projects (H-22722) and (H-23064) will enable this exploratory research. Following consent procedures, participants will be asked to collect samples of skin cells by rubbing the inside of their cheeks with a cotton swab. This procedure is not known to cause any risks or discomforts. Genetic samples will be sent to the study Co-Investigator at Providence Veterans Administration Medical Center for analysis. All samples will be destroyed following data analysis, unless the participant consents to having the sample stored for up to 10 years to enable testing of candidate genes related to hangover etiology.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项遗传学次级研究建议从自愿参加这项研究的H-22722(宿醉、同种人、睡眠和职业表现)和H-23064(醉酒对学生表现的残余影响)的研究参与者池中收集面颊上皮(皮肤)细胞样本，用于DNA分析。这项分析的目的是评估酒精脱氢酶基因(ADH)的遗传差异是否可能缓解宿醉倾向。遗传学数据与父项目(H-22722)和(H-23064)的数据相结合，将使这项探索性研究成为可能。 在同意程序之后，参与者将被要求收集皮肤细胞样本，方法是用棉签摩擦他们的脸颊内侧。目前尚不清楚这一过程是否会造成任何风险或不适。基因样本将被送往普罗维登斯退伍军人管理局医疗中心的研究联合调查员进行分析。所有样本将在数据分析后销毁，除非参与者同意将样本保存长达10年，以便能够测试与宿醉病因相关的候选基因。