GENETIC CORRELATES WITH PROPENSITY FOR HANGOVER: AN EXPLORATORY STUDY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This genetics sub study proposes to collect a sample of cheek epithelial (skin) cells for the purpose of DNA analysis from the pool of study participants in protocols H-22722 (Hangover, Congener, Sleep and Occupational Performance) and H- 23064 (Residual Effects of Intoxication on Student Performance) who volunteer for this study. The objective of this analysis is to assess whether the propensity for hangover, may be moderated by genetic differences in the alcohol dehydrogenase gene (ADH). Genetics data combined with data from the parent projects (H-22722) and (H-23064) will enable this exploratory research. Following consent procedures, participants will be asked to collect samples of skin cells by rubbing the inside of their cheeks with a cotton swab. This procedure is not known to cause any risks or discomforts. Genetic samples will be sent to the study Co-Investigator at Providence Veterans Administration Medical Center for analysis. All samples will be destroyed following data analysis, unless the participant consents to having the sample stored for up to 10 years to enable testing of candidate genes related to hangover etiology.