HANGOVER, CONGENERS, SLEEP, AND OCCUPATIONAL PERFORMANCE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 其目的是调查大量饮酒的残留影响，有或没有宿醉症状。主要目的是检验关于大量饮酒的残余影响的几个假设。关于大量饮酒如何影响第二天表现的假设包括酒精的直接生理效应、酒精戒断效应和非酒精效应，如同类物或酒精问题家族史。我们将检验以下假设：（1）相对于安慰剂，大量饮酒会降低第二天的表现，这种关系将全部或部分由睡眠质量介导;（2）高同源酒精饮料比低同源饮料对表现的影响更大，这种关系将由宿醉症状的严重程度介导。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective is to investigate residual effect of heavy drinking, with or without hangover symptoms. The primary aim is to test several hypotheses about residual effect of heavy drinking. Hypotheses about how heavy drinking effect next- day performance include direct physiological effects of alcohol, alcohol withdrawal effects, and non-ethanol effects, such as congeners or family history of alcohol problems. We will test the following hypotheses: (1) relative to placebo, heavy drinking will degrade next-day performance, and this relationship will be mediated in full or in part by quality of sleep; (2) a high congener alcoholic beverage will affect performance to a greater degree than a low congener beverage and this relationship will be mediated by severity of hangover symptoms.