HEALTH OUTREACH PROGRAM FOR THE ELDERLY (HOPE)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。波士顿大学阿尔茨海默病中心(BU ADC)是美国国立卫生研究院(NIH)资助的32个中心之一，负责提供与阿尔茨海默病(AD)相关的研究、教育和临床护理。BU ADC由5个核心组成：行政、临床、教育和信息传输、神经病理学和小鼠饲养。研究、教育和临床护理的职能是在五个核心之一的主持下完成的。这些核心支持几个重点或感兴趣的领域：阿尔茨海默病的遗传和环境风险、晚期痴呆、家庭和专业护理以及涉及非裔美国人的研究。NIH最近向BU ADC退还了从2001年7月开始的五年期资金。BU ADC临床核心的主要目的是通过提供从门诊和晚期人口中提取的具有良好特征的患者、对照和照顾者群体的信息和材料，促进在BU和全国范围内关于AD的研究。BU ADC已经建立了一个由痴呆症参与者和认知正常的参与者组成的注册中心。这被称为临床核心的患者/控制注册表。在患者/控制登记处登记的患者和对照组每年都要通过标准化的神经学检查和神经心理测试组合进行评估。血液被获取并储存起来，用于分子遗传学研究。还获得了详细的病史、社会史和家族史。这些信息被输入数据库，用于与AD的进展及其对照顾者的影响进行纵向比较和关联。受试者、数据和血液/DNA被提供给合格的研究人员，以促进AD和正常衰老的新研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Boston University Alzheimer's Disease Center (BU ADC) is one of 32 National Institutes of Health (NIH) funded centers mandated to provide research, education and clinical care related to Alzheimer's disease (AD). The BU ADC is comprised of 5 Cores: Administrative, Clinical, Education and Information Transfer, Neuropathology and Murine Breeding. The functions of research, education and clinical care are accomplished under the auspices of one of the five Cores. The Cores support several areas of emphasis or interest: genetic and environmental risks for AD, late stage demetia, family and professional care giving and studies involving African Americans. NIH has recently refunded the BU ADC for a five-year period beginning in July of 2001. The primary purpose of the Clinical Core of the BU ADC is to promote research on AD at BU and throughout the country by providing information and materials from well characterized patient, control and caregiver populations drawn from ambulatory and late-stage populations. The BU ADC has established a Registry comprised of participants with dementia and participants with normal cognition. This is known as the Patient/Control Registry of the Clinical Core. Patients and controls enrolled in the Patient/Control Registry are assessed annually with a standardized neurological examination and neurophsychological test battery. Blood is obtained and stored for molecular genetic studies. A detailed medical, social and family history is also obtained. This information is entered into a database for longitudinal comparisons and correlation with the progression of AD and its impact on caregivers. Subjects, data and blood/DNA are made available to qualified researchers to stimulate new research in AD and normal aging.