Alzheimer's disease translational research training

描述（由申请人提供）：该跨学科博士后培训计划将为有才华的基础博士，临床博士和内科科学家提供密集，结构化的阿尔茨海默病（AD）转化研究培训。利用nia资助的波士顿大学阿尔茨海默病中心和附属教师现有的基础设施和研究优势，该项目将消除基础和临床科学家之间沟通、知识和合作的障碍，并培养研究人员在其专业发展的早期和形成阶段跨越学科界限。通过个性化和小组教学，该奖学金项目将提供(1)阿尔茨海默病的基础和临床基础方面的综合知识，重点关注阿尔茨海默病的环境和遗传风险因素、预防、机制途径、生物标志物、诊断和治疗；(2)基本研究技能的培训（例如，研究的概念化、发展和实施，以及开发新研究方向的创造力）。(3)在学术医学上取得成功的关键专业技能培训（例如，了解可用的资助机制和发展拨款写作技能、口头陈述技能和手稿写作能力）；(4)负责任的研究行为培训，强调动物和人类受试者；(5)综合学员的知识基础、研究和专业技能的高质量联合指导的跨学科研究经验。以及对负责任的研究行为的欣赏，并为实习生作为一名独立的研究者做好准备。完成该项目的学员将在开展和获得AD原创研究资金方面取得学术成功。因此，该项目将填补对越来越多的高素质研究人员的重要需求，这些研究人员有能力推进AD预防、诊断和治疗领域的发展。

DESCRIPTION (provided by applicant): This interdisciplinary post-doctoral training program will provide intensive, structured translational research training in Alzheimer's disease (AD) for a new cadre of talented basic PhD, clinical PhD, and physician scientists. Leveraging the existing infrastructure and research strengths of the NIA-funded Boston University Alzheimer's Disease Center and affiliated faculty, the program will eliminate barriers in communication, knowledge, and collaboration between basic and clinical scientists and train investigators to cross disciplinary boundaries at an early and formative period in their professional development. Through individualized and group didactics, the fellowship program will provide (1) integrated knowledge in the basic and clinical fundamentals of AD, focusing on environmental and genetic risk factors, prevention, mechanistic pathways, biomarkers, diagnostics, and therapeutics of AD, (2) training in essential research skills (e.g., conceptualization, development, and implementation of research studies, and creativity in developing new research directions), (3) training in critical professional skills for success in academic medicine (e.g., understanding available funding mechanisms and development of grant writing skills, oral presentation skills, and manuscript writing abilities), (4) training in the responsible conduct of research, emphasizing both animal and human subjects, and (5) a high quality jointly-mentored, interdisciplinary research experience that synthesizes the trainee's knowledge base, research and professional skill set, and appreciation of responsible conduct of research, and prepares the trainee for independence as an investigator. Trainees completing the program will be well-positioned for academic success in both conducting and securing funding for original research in AD. As a consequence, the program will fill an important need for an increased number of high quality investigators who are well equipped to advance the field of AD prevention, diagnostics, and therapeutics.