Alzheimer's disease translational research training

描述(由申请人提供)：这个跨学科的博士后培训计划将为有才华的基础博士、临床博士和内科科学家的新干部提供阿尔茨海默病(AD)的密集、结构化的翻译研究培训。利用NIA资助的波士顿大学阿尔茨海默病中心及其附属教员现有的基础设施和研究实力，该计划将消除基础和临床科学家之间的沟通、知识和合作障碍，并在他们专业发展的早期和形成阶段培训研究人员跨越学科边界。通过个别化和小组教学，研究金方案将提供(1)AD基础和临床基础的综合知识，重点是AD的环境和遗传风险因素、预防、机制途径、生物标记物、诊断和治疗，(2)基本研究技能的培训(例如，概念化、研究的发展和实施，以及开发新研究方向的创造力)，(3)学术医学成功的关键专业技能培训(例如，了解现有的资助机制和发展拨款撰写技能、口头陈述技能和手稿写作能力)，(4)负责任的研究行为培训，强调动物和人类研究对象，以及(5)高质量的联合指导的跨学科研究经验，综合受训者的知识基础、研究和专业技能以及对负责任的研究行为的欣赏，并为受训者成为一名独立的调查员做好准备。完成该计划的学员将在进行AD原创研究并获得资金方面取得学术成功。因此，该计划将满足对更多高素质调查人员的重要需求，这些调查人员装备精良，能够推动AD预防、诊断和治疗领域的发展。

DESCRIPTION (provided by applicant): This interdisciplinary post-doctoral training program will provide intensive, structured translational research training in Alzheimer's disease (AD) for a new cadre of talented basic PhD, clinical PhD, and physician scientists. Leveraging the existing infrastructure and research strengths of the NIA-funded Boston University Alzheimer's Disease Center and affiliated faculty, the program will eliminate barriers in communication, knowledge, and collaboration between basic and clinical scientists and train investigators to cross disciplinary boundaries at an early and formative period in their professional development. Through individualized and group didactics, the fellowship program will provide (1) integrated knowledge in the basic and clinical fundamentals of AD, focusing on environmental and genetic risk factors, prevention, mechanistic pathways, biomarkers, diagnostics, and therapeutics of AD, (2) training in essential research skills (e.g., conceptualization, development, and implementation of research studies, and creativity in developing new research directions), (3) training in critical professional skills for success in academic medicine (e.g., understanding available funding mechanisms and development of grant writing skills, oral presentation skills, and manuscript writing abilities), (4) training in the responsible conduct of research, emphasizing both animal and human subjects, and (5) a high quality jointly-mentored, interdisciplinary research experience that synthesizes the trainee's knowledge base, research and professional skill set, and appreciation of responsible conduct of research, and prepares the trainee for independence as an investigator. Trainees completing the program will be well-positioned for academic success in both conducting and securing funding for original research in AD. As a consequence, the program will fill an important need for an increased number of high quality investigators who are well equipped to advance the field of AD prevention, diagnostics, and therapeutics.