Boston University Alzheimer's Disease Research Center

波士顿大学阿尔茨海默病研究中心(BU ADRC)致力于实现这些目标和 国家适应行动方案的战略包括：到2025年预防和有效治疗阿尔茨海默病和阿尔茨海默病相关痴呆 扩大AD/ADRD研究；加快努力确定AD/ADRD的早期和症状前阶段； 并教育公众有关AD/ADRD的知识。BU ADRC的研究主题与NIH AD/ADRD一致 研究峰会的建议包括：1)关于异质性和多因素性质的研究 AD/ADRD；2)现有和新的队列的分子图谱；以及3)发展新的公共-私营部门 合伙企业。我们通过7个紧密集成的核心实现我们的使命：行政、临床(CC)、 数据管理和统计(DMS)、生物标记物、神经病理学(NPC)、外联/招聘、 参与(ORE)、遗传学和分子图谱(GMP)和研究教育部分(REC)。 核心集中在尖端研究、积极的社区参与、下一步的培训 生成AD/ADRD临床医生和研究人员，并在 重要的合作伙伴和整个社区。BU ADRC为以下方面做出了重大贡献 AD/ADRD研究在全国范围内显著增长，并积极参与了参与者、生物学 样本、临床数据和科学专业知识提供给所有主要的国家AD/ADRD研究计划。公安部 ADRC一直是令人兴奋的关于遗传和寿命环境风险因素和 AD/ADRD，特别是血管风险和接触接触运动的重复头部撞击(RHI)，军事 服务和其他来源。北卡罗来纳大学ADRC的主要研究主题包括接触性运动和 服兵役与AD/ADRD风险，包括慢性创伤性脑病(CTE)和深部 表型AD/ADRD异质性与一系列互补的创新方法，包括数字 和脑电表型；神经病理学；遗传学；生物统计模型；生物标记物的发现；以及分子 侧写。BU ADRC将在这一强劲成就记录的基础上，支持新的研究和 培养下一代AD/ADRD科学家。BU ADRC也将支持高风险高收益 创新的发展项目侧重于国家适应行动方案和国家行动局的战略目标，并利用我们的集体专长 和经验，以促进不同背景的调查人员的职业发展。BU ADRC将 发展新的伙伴关系，加强与其他发展研究中心和国家研究机构的现有伙伴关系 项目、基金会、倡导团体和私人组织，共同努力预防和治疗AD/ADRD。 暴露于RHI与CTE和其他一系列AD/ADRD病理有关。公认的 作为这一领域的领先者，我们在支持遗传和其他风险因素和 研究RHI如何影响AD/ADRD的临床病程、生物标志物分布和临床病理特征 包括CTE。

The Boston University Alzheimer's Disease Research Center (BU ADRC) is committed to the goals and strategies of NAPA including: to prevent and effectively treat AD and AD related dementias (ADRD) by 2025 by expanding AD/ADRD research; to accelerate efforts to identify early and pre-symptomatic stages of AD/ADRD; and to educate the public about AD/ADRD. BU ADRC research themes are congruent with NIH AD/ADRD Research Summit recommendations including: 1) research on heterogeneity and the multifactorial nature of AD/ADRD; 2) molecular profiling of existing and new cohorts; and 3) developing new public-private partnerships. We operationalize our mission through 7 tightly integrated cores: Administrative, Clinical (CC), Data Management and Statistics (DMS), Biomarker, Neuropathology (NPC), Outreach/Recruitment, Engagement (ORE), Genetics and Molecular Profiling (GMP) and a research education component (REC). The Cores are focused on cutting edge research, proactive community engagement, training the next generation of AD/ADRD clinicians and researchers, and sharing key material, data, and expertise both among key partners and with the community at large. The BU ADRC has made significant contributions to the remarkable growth of AD/ADRD research nationally and has actively contributed participants, biological samples, clinical data, and scientific expertise to all major national AD/ADRD research initiatives. The BU ADRC has been the catalyst for exciting new research on genetic and lifespan environmental risk factors and AD/ADRD, particularly vascular risk and exposure to repetitive head impacts (RHI) from contact sports, military service and other sources. Major BU ADRC research themes include studies on RHI from contact sports and military service and risk for AD/ADRD, including chronic traumatic encephalopathy (CTE) and deep phenotyping AD/ADRD heterogeneity with a range of complementary innovative approaches including digital and EEG phenotyping; neuropathology; genetics; biostatistical modelling; biomarker discovery; and molecular profiling. The BU ADRC will build on this strong record of accomplishment to support new research and educate the next generation of AD/ADRD scientists. The BU ADRC will also support high risk high gain innovative developmental projects focused on NAPA and NIA strategic goals and utilize our collective expertise and experience to facilitate career development of investigators with diverse backgrounds. The BU ADRC will develop new partnerships and enhance current partnerships with other ADRCs and national research programs, foundations, advocacy groups and private organizations in our quest to prevent and treat AD/ADRD. Exposure to RHI is associated with CTE and a wide range of other AD/ADRD pathologies. As recognized leaders in this space, we are uniquely positioned to support research on genetic and other risks factors and study how RHI affects the clinical course, biomarker profile, and clinical-pathological features of AD/ADRD including CTE.