Epigenetic mechanisms relevant to the pathogenesis of ALS

ALS发病机制相关的表观遗传机制

基本信息

  • 批准号:
    8245574
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-01-01 至 2014-12-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Amyotrophic Lateral Sclerosis (ALS) is a fatal disease characterized by progressive paralysis due to motor neuron degeneration. Many therapies have been tested but no cure or effective therapy is available. Mutations of superoxide dismutase-1 (SOD1) are a cause of familial ALS and it is widely held that oxidative injury is likely to be a major contributor to disease pathogenesis. Despite this, the cause of motor neuron death is unknown and the role of mutant SOD1 in the generation of oxidative stress in ALS has not been established. We recently reported that the amino acid L-arginine slows disease progression in mutant SOD1 (G93A) transgenic ALS mice. The basis for this neuroprotective effect is not known but one possible mechanism may involve the production of neuroprotective polyamines that are potential substrates for LSD1, a key enzyme regulating protein methylation that shares considerable homology with FAD-dependent polyamine oxidases. We found that LSD1 expression suppresses transcription in transiently transfected SH-SY5Y neuroblastoma cells suggesting that LSD1 expression can regulate transcriptional activity in neurons. We also found that LSD1 enzyme activity is increased the spinal cords of G93A mice and that levels of dimethylated histone H3 Lys4 (DMH3K4), a substrate of LSD1, were reduced. In contrast, levels of trimethylated histone H3 Lys4 (TMH3K4), which is not demethylated by LSD1, were unchanged. Because of this, we examined the relationship between the expression of LSD1 and the neuroprotective effects of the polyamine, spermidine. We found that spermidine treatment reduced neuronal loss and gliosis in G93A mice and restored LSD1 activity to normal levels. To directly test the role of LSD1 in the pathogenesis of oxidative injury in neurons, we treated NSC-34 motor neuronal cells transfected with LSD1 shRNA with hydrogen peroxide and found that reduced LSD1 expression was associated with resistance to oxidative injury further supporting a possible link between oxidative injury, LSD1 expression and neurodegeneration in G93A mice. Based on these observations we hypothesize that increased LSD1 expression may contribute to motor neuron degeneration in ALS by altering histone and/or non-histone protein methylation. Interventions that reduce LSD1 expression may therefore protect neurons from degeneration in G93A mice. In the current proposal we plan to study the relationship between LSD1 expression, protein methylation and neurodegeneration in the G93A mice. We will also test the effects of LSD1 inhibitors on the behavioral and neuropathological phenotype of G93A mice. The specific aims of the study are: 1) To determine the relationship between LSD1 induction in motor neurons and cell death mediated by oxidative stress in vitro; 2) To determine the role of LSD1 in the survival of motor neurons harboring the G93A SOD1 mutation; and 3) To investigate the therapeutic effect of LSD1 modulators on motor neuron degeneration, neuropathology, clinical progression, and the survival of G93A mice. A variety of complementary methods will be used to accomplish our aims. We will determine the importance of LSD1 in oxidative injury and G93A-mediated neurotoxicity by transiently knocking down LSD1 expression with shRNA in NSC-34 cells and in cultured primary motor neurons and in NSC-34 cells stably transfected with either Tet- inducible LSD1 or a shRNA expression system to suppress LSD1 translation. We will measure LSD1 gene expression and activity levels using Real-Time PCR, Western blotting, immunofluorescent staining and by assessing transcriptional activity using a luciferase assay and the methylation of histone H3K4 using specific antibodies. We will determine the effect of spermidine and tranylcypromine, an LSD1 inhibitor on LSD1 activity and DMH3K4 levels and anti-oxidant gene expression in G93A mice. In addition, we will investigate the effects of these drugs on neuropathology, behavior and survival of G93A mice. We hope that our studies will lay the foundation for the development of better treatments for this fatal condition that disproportionately affects veterans who have been deployed to the Persian Gulf region. PUBLIC HEALTH RELEVANCE: Amyotrophic lateral sclerosis (ALS or Lou Gehrig disease) is an untreatable fatal progressive neurological disease characterized by degeneration of the motor system. Gulf War veterans may have an increased risk of ALS compared to veterans who did not serve in the Gulf. The reasons for this increased risk are not known but it is thought to be due to exposure to a neurotoxin in the environment. The studies we propose are designed to better understand the causes of motor neuron degeneration in a well-characterized mouse model of ALS. This transgenic mouse is produced by adding the abnormal human gene that causes ALS to the mouse embryo. These mice develop progressive weakness and die prematurely at about 4 months of age. We expect that our studies on how motor neurons degenerate will lay the foundation for the development of better treatments for this irreversible progressive and fatal condition. The urgent need for such studies is highlighted by the prospect that hundreds of thousands of future veterans may be at increased risk for this devastating disease.
描述(由申请人提供): 肌萎缩侧索硬化症(ALS)是一种以运动神经元变性引起的进行性瘫痪为特征的致命性疾病。已经测试了许多治疗方法,但没有治愈或有效的治疗方法。超氧化物歧化酶-1(SOD1)基因突变是家族性肌萎缩侧索硬化症的病因之一,人们普遍认为氧化损伤可能是疾病发病的主要因素。尽管如此,运动神经元死亡的原因尚不清楚,突变的SOD1在肌萎缩侧索硬化症氧化应激产生中的作用尚未确定。我们最近报道了氨基酸L-精氨酸延缓了突变型SOD1G93A转基因ALS小鼠的疾病进展。这种神经保护作用的基础尚不清楚,但一个可能的机制可能涉及神经保护性多胺的产生,这些多胺是LSD1的潜在底物,LSD1是调节蛋白质甲基化的关键酶,与FAD依赖的多胺氧化酶有相当大的同源性。我们发现LSD1的表达抑制了瞬时转染的SH-SY5Y神经母细胞瘤细胞的转录,提示LSD1的表达可以调节神经元的转录活性。我们还发现,LSD1酶的活性在G93A小鼠的脊髓中增加,而作为LSD1底物的二甲基化组蛋白H3Lys4(DMH3K4)的水平降低。相反,未被LSD1去甲基化的三甲基化组蛋白H3Lys4(TMH3K4)的水平没有变化。因此,我们研究了LSD1的表达与多胺、亚精胺的神经保护作用之间的关系。我们发现,亚精胺治疗减少了G93A小鼠的神经元丢失和胶质细胞增生,并将LSD1活性恢复到正常水平。为了直接测试LSD1在神经元氧化损伤发病机制中的作用,我们用过氧化氢处理转LSD1 shRNA的NSC-34运动神经元细胞,发现LSD1表达降低与G93A小鼠对氧化损伤的抵抗有关,进一步支持了氧化损伤、LSD1表达与神经变性之间的可能联系。基于这些观察,我们推测LSD1表达增加可能通过改变组蛋白和/或非组蛋白甲基化而导致ALS运动神经元变性。因此,减少LSD1表达的干预措施可能会保护G93A小鼠的神经元免受退化。在目前的方案中,我们计划研究G93A小鼠LSD1表达、蛋白质甲基化和神经退行性变之间的关系。我们还将测试LSD1抑制剂对G93A小鼠行为和神经病理表型的影响。本研究的具体目的是:1)确定体外氧化应激诱导运动神经元LSD1表达与细胞死亡的关系;2)确定LSD1在携带G93A SOD1突变的运动神经元存活中的作用;3)探讨LSD1调节剂对G93A小鼠运动神经元变性、神经病理、临床进展和存活的治疗作用。我们将使用多种互补的方法来实现我们的目标。我们将通过在NSC-34细胞和培养的原代运动神经元中用shRNA瞬时下调LSD1的表达,以及在稳定转染Tet诱导的LSD1或shRNA表达系统以抑制LSD1翻译的NSC-34细胞中,确定LSD1在氧化损伤和G93A介导的神经毒性中的重要性。我们将使用Real-Time PCR、Western blotting、免疫荧光染色以及使用荧光素酶实验评估转录活性和使用特定抗体评估组蛋白H3K4的甲基化来测量LSD1基因的表达和活性水平。我们将确定亚精胺和三羟环丙胺(一种LSD1抑制剂)对G93A小鼠LSD1活性、DMH3K4水平和抗氧化基因表达的影响。此外,我们还将研究这些药物对G93A小鼠神经病理、行为和存活的影响。我们希望,我们的研究将为开发更好的治疗这种致命疾病奠定基础,这种致命疾病对已被部署到波斯湾地区的退伍军人造成不成比例的影响。 公共卫生相关性: 肌萎缩侧索硬化症(ALS或Lou Gehrig病)是一种无法治疗的以运动系统退化为特征的致命进行性神经系统疾病。与没有在海湾服役的退伍军人相比,海湾战争退伍军人患ALS的风险可能会增加。风险增加的原因尚不清楚,但人们认为这是由于暴露在环境中的一种神经毒素。我们提出的研究旨在更好地了解ALS小鼠模型中运动神经元退化的原因。这种转基因小鼠是通过在小鼠胚胎中添加导致肌萎缩侧索硬化症的异常人类基因而产生的。这些小鼠逐渐变得虚弱,并在大约4个月大的时候过早死亡。我们期望我们对运动神经元如何退化的研究将为开发更好的治疗这种不可逆转的、进行性的和致命的疾病奠定基础。未来数十万退伍军人患这种毁灭性疾病的风险可能会增加,这突显了此类研究的迫切需要。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
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Neil W. Kowall其他文献

Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease
  • DOI:
    10.1186/s13059-025-03564-z
  • 发表时间:
    2025-07-17
  • 期刊:
  • 影响因子:
    9.400
  • 作者:
    Farid Rajabli;Penelope Benchek;Giuseppe Tosto;Nicholas Kushch;Jin Sha;Katrina Bazemore;Congcong Zhu;Wan-Ping Lee;Jacob Haut;Kara L. Hamilton-Nelson;Nicholas R. Wheeler;Yi Zhao;John J. Farrell;Michelle A. Grunin;Yuk Yee Leung;Pavel P. Kuksa;Donghe Li;Eder Lucio da Fonseca;Jesse B. Mez;Ellen L. Palmer;Jagan Pillai;Richard M. Sherva;Yeunjoo E. Song;Xiaoling Zhang;Takeshi Ikeuchi;Taha Iqbal;Omkar Pathak;Otto Valladares;Dolly Reyes-Dumeyer;Amanda B. Kuzma;Erin Abner;Larry D. Adams;Perrie M. Adams;Alyssa Aguirre;Marilyn S. Albert;Roger L. Albin;Mariet Allen;Lisa Alvarez;Liana G. Apostolova;Steven E. Arnold;Sanjay Asthana;Craig S. Atwood;Sanford Auerbach;Gayle Ayres;Clinton T. Baldwin;Robert C. Barber;Lisa L. Barnes;Sandra Barral;Thomas G. Beach;James T. Becker;Gary W. Beecham;Duane Beekly;Bruno A. Benitez;David Bennett;John Bertelson;Thomas D. Bird;Deborah Blacker;Bradley F. Boeve;James D. Bowen;Adam Boxer;James Brewer;James R. Burke;Jeffrey M. Burns;Joseph D. Buxbaum;Nigel J. Cairns;Laura B. Cantwell;Chuanhai Cao;Christopher S. Carlson;Cynthia M. Carlsson;Regina M. Carney;Minerva M. Carrasquillo;Scott Chasse;Marie-Francoise Chesselet;Nathaniel A. Chin;Helena C. Chui;Jaeyoon Chung;Suzanne Craft;Paul K. Crane;David H. Cribbs;Elizabeth A. Crocco;Carlos Cruchaga;Michael L. Cuccaro;Munro Cullum;Eveleen Darby;Barbara Davis;Philip L. De Jager;Charles DeCarli;John DeToledo;Malcolm Dick;Dennis W. Dickson;Beth A. Dombroski;Rachelle S. Doody;Ranjan Duara;NIlüfer Ertekin-Taner;Denis A. Evans;Kelley M. Faber;Thomas J. Fairchild;Kenneth B. Fallon;David W. Fardo;Martin R. Farlow;Victoria Fernandez-Hernandez;Steven Ferris;Robert P. Friedland;Tatiana M. Foroud;Matthew P. Frosch;Brian Fulton-Howard;Douglas R. Galasko;Adriana Gamboa;Marla Gearing;Daniel H. Geschwind;Bernardino Ghetti;John R. Gilbert;Rodney C.P. Go;Alison M. Goate;Thomas J. Grabowski;Neill R. Graff-Radford;Robert C. Green;John H. Growdon;Hakon Hakonarson;James Hall;Ronald L. Hamilton;Oscar Harari;John Hardy;Lindy E. Harrell;Elizabeth Head;Victor W. Henderson;Michelle Hernandez;Timothy Hohman;Lawrence S. Honig;Ryan M. Huebinger;Matthew J. Huentelman;Christine M. Hulette;Bradley T. Hyman;Linda S. Hynan;Laura Ibanez;Gail P. Jarvik;Suman Jayadev;Lee-Way Jin;Kim Johnson;Leigh Johnson;M. Ilyas Kamboh;Anna M. Karydas;Mindy J. Katz;John S. Kauwe;Jeffrey A. Kaye;C. Dirk Keene;Aisha Khaleeq;Masataka Kikuchi;Ronald Kim;Janice Knebl;Neil W. Kowall;Joel H. Kramer;Walter A. Kukull;Frank M. LaFerla;James J. Lah;Eric B. Larson;Alan Lerner;James B. Leverenz;Allan I. Levey;Andrew P. Lieberman;Richard B. Lipton;Mark Logue;Oscar L. Lopez;Kathryn L. Lunetta;Constantine G. Lyketsos;Douglas Mains;Flanagan E. Margaret;Daniel C. Marson;Eden RR. Martin;Frank Martiniuk;Deborah C. Mash;Eliezer Masliah;Paul Massman;Arjun Masurkar;Wayne C. McCormick;Susan M. McCurry;Andrew N. McDavid;Stefan McDonough;Ann C. McKee;Marsel Mesulam;Bruce L. Miller;Carol A. Miller;Joshua W. Miller;Thomas J. Montine;Edwin S. Monuki;John C. Morris;Shubhabrata Mukherjee;Amanda J. Myers;Trung Nguyen;Thomas Obisesan;Sid O’Bryant;John M. Olichney;Marcia Ory;Raymond Palmer;Joseph E. Parisi;Henry L. Paulson;Valory Pavlik;David Paydarfar;Victoria Perez;Elaine Peskind;Ronald C. Petersen;Helen Petrovitch;Aimee Pierce;Marsha Polk;Wayne W. Poon;Huntington Potter;Liming Qu;Mary Quiceno;Joseph F. Quinn;Ashok Raj;Murray Raskind;Eric M. Reiman;Barry Reisberg;Joan S. Reisch;John M. Ringman;Erik D. Roberson;Monica Rodriguear;Ekaterina Rogaeva;Howard J. Rosen;Roger N. Rosenberg;Donald R. Royall;Marwan Sabbagh;A. Dessa Sadovnick;Mark A. Sager;Mary Sano;Andrew J. Saykin;Julie A. Schneider;Lon S. Schneider;William W. Seeley;Susan H. Slifer;Scott Small;Amanda G. Smith;Janet P. Smith;Joshua A. Sonnen;Salvatore Spina;Peter St George-Hyslop;Takiyah D. Starks;Robert A. Stern;Alan B. Stevens;Stephen M. Strittmatter;David Sultzer;Russell H. Swerdlow;Rudolph E. Tanzi;Jeffrey L. Tilson;John Q. Trojanowski;Juan C. Troncoso;Magda Tsolaki;Debby W. Tsuang;Vivianna M. Van Deerlin;Linda J. van Eldik;Jeffery M. Vance;Badri N. Vardarajan;Robert Vassar;Harry V. Vinters;Jean-Paul Vonsattel;Sandra Weintraub;Kathleen A. Welsh-Bohmer;Patrice L. Whitehead;Ellen M. Wijsman;Kirk C. Wilhelmsen;Benjamin Williams;Jennifer Williamson;Henrik Wilms;Thomas S. Wingo;Thomas Wisniewski;Randall L. Woltjer;Martin Woon;Clinton B. Wright;Chuang-Kuo Wu;Steven G. Younkin;Chang-En Yu;Lei Yu;Xiongwei Zhu;Brian W. Kunkle;William S. Bush;Akinori Miyashita;Goldie S. Byrd;Li-San Wang;Lindsay A. Farrer;Jonathan L. Haines;Richard Mayeux;Margaret A. Pericak-Vance;Gerard D. Schellenberg;Gyungah R. Jun;Christiane Reitz;Adam C. Naj
  • 通讯作者:
    Adam C. Naj
Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer’s Disease Neuroimaging Initiative cohort
多组学分析探索阿尔茨海默病神经影像倡议队列中的血液代谢生物标志物
  • DOI:
    10.1038/s41598-024-56837-1
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Takaki Oka;Yuki Matsuzawa;Momoka Tsuneyoshi;Yoshitaka Nakamura;Ken Aoshima;H. Tsugawa;Michael Paul Ronald Clifford R. William John Q. Arthur W. Weiner Aisen Petersen Jack Jagust Trojanowki Toga ;Michael Weiner;P. Aisen;Ron Petersen;Clifford R Jack;William Jagust;J. Trojanowki;Arthur W Toga;L. Beckett;Robert C. Green;Andrew J. Saykin;John C. Morris;Leslie M. Shaw;Enchi Liu;T. Montine;R. G. Thomas;Michael Donohue;Sarah Walter;D. Gessert;T. Sather;G. Jiminez;Danielle Harvey;M. Bernstein;Nick Fox;Paul Thompson;N. Schuff;Charlie S. DeCarli;B. Borowski;J. Gunter;Matthew Senjem;P. Vemuri;David Jones;K. Kantarci;C. Ward;Robert A. Koeppe;Norman L. Foster;Eric M Reiman;Kewei Chen;C. Mathis;Susan Landau;Nigel J. Cairns;E. Householder;Lisa Taylor Reinwald;V. Lee;M. Korecka;M. Figurski;K. Crawford;S. Neu;Tatiana M Foroud;S. Potkin;L. Shen;Faber Kelley;Sungeun Kim;K. Nho;Zaven Kachaturian;Richard Frank;Peter J. Snyder;S. Molchan;J. Kaye;Joseph Quinn;B. Lind;R. Carter;S. Dolen;Lon S. Schneider;S. Pawluczyk;Mauricio Beccera;L. Teodoro;B. Spann;J. Brewer;H. Vanderswag;A. Fleisher;J. Heidebrink;J. Lord;S. Mason;C. Albers;D. Knopman;K. Johnson;Rachelle S. Doody;Javier Villanueva Meyer;M. Chowdhury;S. Rountree;M. Dang;Y. Stern;Lawrence S. Honig;Karen L. Bell;B. Ances;John C. Morris;M. Carroll;Sue Leon;E. Householder;M. Mintun;S. Schneider;A. Oliver;D. Marson;R. Griffith;D. Clark;David S Geldmacher;J. Brockington;Erik Roberson;H. Grossman;Effie M. Mitsis;L. de Toledo‐Morrell;R. Shah;R. Duara;D. Varon;Maria T. Greig;Peggy Roberts;Marilyn S. Albert;C. Onyike;D. D’Agostino;S. Kielb;James E. Galvin;D. Pogorelec;Brittany Cerbone;Christina A. Michel;H. Rusinek;Mony J. de Leon;Lidia Glodzik;S. de Santi;P. Doraiswamy;J. Petrella;T. Wong;Steven E. Arnold;J. Karlawish;David A. Wolk;Charles D. Smith;G. Jicha;Peter Hardy;P. Sinha;Elizabeth Oates;G. Conrad;Oscar L. Lopez;M. Oakley;D. Simpson;A. Porsteinsson;B. Goldstein;K. Martin;K. Makino;M. Ismail;C. Brand;R. Mulnard;G. Thai;Catherine Mc Adams Ortiz;Kyle Womack;D. Mathews;M. Quiceno;R. D. Arrastia;Richard D. King;Myron Weiner;K. M. Cook;Michael D. Devous;A. Levey;J. Lah;J. Cellar;Jeffrey M. Burns;H. Anderson;R. Swerdlow;Liana G. Apostolova;K. Tingus;Ellen Woo;Daniel H. S. Silverman;Po H. Lu;G. Bartzokis;Neill R. Graff Radford;F. Parfitt;Tracy Kendall;Heather K. Johnson;Marty Farlow;A. Hake;Brandy R. Matthews;S. Herring;Cynthia Hunt;Christopher H. van Dyck;Richard E. Carson;M. Macavoy;H. Chertkow;Howard Bergman;C. Hosein;S. Black;B. Stefanovic;Curtis Caldwell;G. R. Hsiung;H. Feldman;B. Mudge;M. Assaly;Andrew Kertesz;J. Rogers;D. Trost;C. Bernick;D. Munic;D. Kerwin;M.;K. Lipowski;Chuang‐Kuo Wu;N. Johnson;C. Sadowsky;Walter Martínez;Teresa Villena;R. S. Turner;K. Johnson;B. Reynolds;R. Sperling;Keith A. Johnson;G. Marshall;Meghan T. Frey;Jerome A. Yesavage;Joy Taylor;B. Lane;A. Rosen;Jared S. Tinklenberg;M. Sabbagh;C. Belden;S. Jacobson;Sherye A. Sirrel;Neil W. Kowall;Ronald J Killiany;A. Budson;A. Norbash;P. L. Johnson;T. Obisesan;S. Wolday;Joanne S. Allard;Alan J Lerner;P. Ogrocki;Leon Hudson;E. Fletcher;O. Carmichael;J. Olichney;Charlie S. DeCarli;S. Kittur;Michael Borrie;T. Lee;Rob Bartha;S. Johnson;Sanjay Asthana;C. Carlsson;S. Potkin;Adrian Preda;D. Nguyen;P. Tariot;A. Fleisher;Stephanie A. Reeder;V. Bates;H. Capote;M. Rainka;D. Scharre;M. Kataki;Anahita Adeli;E. Zimmerman;D. Celmins;Alice D. Brown;G. D. Pearlson;K. Blank;K. Anderson;R. Santulli;T. Kitzmiller;Eben S. Schwartz;K. Sink;J. Williamson;P. Garg;F. Watkins;Brian R. Ott;H. Querfurth;G. Tremont;S. Salloway;P. Malloy;Stephen Correia;H. Rosen;Bruce L. Miller;Jacobo Mintzer;K. Spicer;David Bachman;E. Finger;S. Pasternak;I. Rachinsky;J. Rogers;Andrew Kertesz;D. Drost;N. Pomara;R. Hernando;A. Sarrael;Susan K. Schultz;L. Ponto;H. Shim;K. Smith;N. Relkin;G. Chaing;Lisa Raudin;Amanda G. Smith;K. Fargher;B. A. Raj
  • 通讯作者:
    B. A. Raj
Case 7-1988
案例7-1988
  • DOI:
  • 发表时间:
    1988
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Neil W. Kowall;R. A. Sobel
  • 通讯作者:
    R. A. Sobel
VA’s National PTSD Brain Bank: a National Resource for Research
  • DOI:
    10.1007/s11920-017-0822-6
  • 发表时间:
    2017-08-25
  • 期刊:
  • 影响因子:
    6.700
  • 作者:
    Matthew J. Friedman;Bertrand R. Huber;Christopher B. Brady;Robert J. Ursano;David M. Benedek;Neil W. Kowall;Ann C. McKee
  • 通讯作者:
    Ann C. McKee
p75NTR Antagonistic Cyclic Peptide Decreases the Size of β Amyloid-Induced Brain Inflammation
  • DOI:
    10.1007/s10571-008-9298-6
  • 发表时间:
    2008-09-19
  • 期刊:
  • 影响因子:
    4.800
  • 作者:
    Mina Yaar;Bennet L. Arble;Kenneth B. Stewart;Nazer H. Qureshi;Neil W. Kowall;Barbara A. Gilchrest
  • 通讯作者:
    Barbara A. Gilchrest

Neil W. Kowall的其他文献

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{{ truncateString('Neil W. Kowall', 18)}}的其他基金

Boston University Alzheimer's Disease Research Center
波士顿大学阿尔茨海默病研究中心
  • 批准号:
    10264287
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Core A: Administrative Core
核心A:行政核心
  • 批准号:
    10468306
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Core A: Administrative Core
核心A:行政核心
  • 批准号:
    10264288
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Core A: Administrative Core
核心A:行政核心
  • 批准号:
    10652549
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
VA Biorepository Brain Bank
VA 生物储存库脑库
  • 批准号:
    8661513
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
VA Biorepository: Gulf War Veterans' Illnesses Biorepository
VA 生物储存库:海湾战争退伍军人疾病生物储存库
  • 批准号:
    9402030
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
Epigenetic mechanisms relevant to the pathogenesis of ALS
ALS发病机制相关的表观遗传机制
  • 批准号:
    8597391
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
Epigenetic mechanisms relevant to the pathogenesis of ALS
ALS发病机制相关的表观遗传机制
  • 批准号:
    8043487
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
Alzheimer's disease translational research training
阿尔茨海默病转化研究培训
  • 批准号:
    8446333
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
Alzheimer's disease translational research training
阿尔茨海默病转化研究培训
  • 批准号:
    8660258
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
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