MEASUREMENT OF DOPAMINE SYSTEMS IN SUBJECTS AT-RISK FOR ALCOHOLISM

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。比较HR和LR(低危)受试者的局部脑葡萄糖代谢。我们假设，在HR受试者中，酒精中毒的一个易感因素是Fc活性降低，因为该区域与缺乏控制和包括酒精中毒在内的成瘾所特有的强迫药物消费有关。比较D2-R在酒精中毒高危人群(HR)和酒精中毒低危人群(LR)中的可用性。我们假设HR受试者酒精中毒的保护因素是由于高D2-R，我们假设这是通过调节大脑奖赏回路对酒精中毒的反应来保护他们免受酒精中毒的影响。比较急性酒精摄入(0.75g/kg)引起的局部代谢变化，并评估D2-R在HR和LR受试者对急性酒精中毒反应中的影响。我们假设，与酒精中毒(无酒精中毒家族史)的低风险受试者相比，HR受试者对酒精中毒的行为和局部脑代谢反应会降低。我们进一步假设，酒精诱导的代谢和行为效应将受到OFC中D2-R水平和活性的调节

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To compare regional brain glucose metabolism in HR and LR (low-risk) subjects. We hypothesize that a vulnerability factor for alcoholism in HR subjects is decreased OFC activity since this region is implicated in the lack of control and compulsive drug consumption characteristic of addictions including alcoholism. To compare D2-R availability in subjects with high risk (HR) for alcoholism and low risk (LR) for alcoholism. We hypothesize that a protective factor for alcoholism in HR subjects is due to high D2-R, which we postulate protects them against alcoholism by regulating the response of brain reward circuits to alcohol intoxication.To compare the regional metabolic changes induced by acute alcohol administration (0.75 g/kg) and to evaluate the influence of D2-R in the responses to acute alcohol intoxication between HR and LR subjects. We hypothesize that HR subjects will have reduced behavioral and regional brain metabolic responses to alcohol intoxication when compared with subjects at low risk for alcoholism (LR) (negative family history of alcoholism). We further hypothesize that alcohol-induced metabolic and behavioral effects will be modulated by D2-R levels and activity in OFC