REGULATION OF MUSCLE AND HEPATIC TRIGLYCERIDE AND INSULIN RESISTANCE IN BURNED

烧伤时肌肉和肝脏甘油三酯及胰岛素抵抗的调节

• 批准号: 7378717
• 负责人: ROBERT R WOLFE
• 金额: $ 0.03万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378717
• 关键词: REGULATION; MUSCLE; HEPATIC; TRIGLYCERIDE; INSULIN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to study why children with burns develop large amounts of fat in their liver, and high levels of sugar in their blood. 2 new drugs (Propranolo and fenofibrate) will be tested to see if they can help correct these problems. The entire study will be performed at the Shriners Hospital with the exception of the MRI. The MRI will be used to measure the amount of fat inside the leg and the liver following the various treatments

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是研究为什么烧伤儿童会在肝脏中产生大量脂肪，并在血液中产生高水平的血糖。两种新药(普奈洛尔和非诺贝特)将接受测试，看看它们是否能帮助纠正这些问题。整个研究将在施林内斯医院进行，但核磁共振除外。核磁共振将被用来测量各种治疗后腿部和肝脏内的脂肪量。