RESTING ENERGY EXPENDITURE AND AMINO ACID SUPPLEMENTAITON IN YOUNG HEALTHY AD

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。背景：关于EAA在人类中的时间过程知之甚少。因此，该项目的目的是支持我们对肌肉蛋白质代谢和营养的持续兴趣，使用EAA的混合物。 具体目的和程序：我们假设，与水对照相比，年轻健康成人的能量消耗将更高。我们将使用一台计算机来测量年轻健康成年人的静息能量消耗，该计算机测量静息时消耗的氧气和产生的二氧化碳的速率。到达后，受试者将签署知情同意书，并将获得生命体征、体重和身高。受试者将服用15克蛋白质，并在气泡下进行两次单独的2小时呼吸，两次呼吸之间有一个方便的休息时间，受试者将去洗手间或拉伸以减少姿势痉挛或僵硬。短暂休息后，将测量另一个两小时的气体测量块。在该测试之后，将使用低水平X射线机（DEXA）测量身体成分测试。 重要性：这项研究的吸引力在于，在卡路里数量有限的情况下，有可能增加身体虚弱和/或运动能力有限的人的能量消耗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Little is known about the time course of the EAA in humans. Therefore the purpose of the project is to support our ongoing interests in muscle protein metabolism and nutrition using a blend of EAA. Specific Aims and Procedures: We hypothesize that energy expenditure will be higher in younger healthy adults compared to the water control. We will measure resting energy expenditure in young healthy adults using a computer that measures the rate of oxygen consumed and carbon dioxide produced at rest. Upon arriving the subject will be consented and vital signs and weight and height will be obtained. The subject will take 15 grams of protein and have two separate 2-hour blocks of breathing under a bubble separated by a convenience break in which the subject will either go to the bathroom or stretch to reduce positional cramps or stiffness. Following a brief break, another two hour block of gas measurements will be measured. Following this test a body composition test will be measured using a low level x-ray machine (DEXA). Significance: The appeal of this study is that with a limited number of calories it might be possible to increase energy expenditures in persons who are infirmed and or those who have limited exercise capacity.