NUTRITIONAL SUPPLEMENTATION AND INSULIN RESISTANCE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。简要背景：在这项研究中，我们将研究胰岛素(一种调节体内葡萄糖和脂肪加工的重要激素)的效果已经减弱的人肌肉和肝脏中积累的脂肪是否可以通过摄入特定的营养物质来改变，例如鱼油和氨基酸(蛋白质的组成部分)。具体目标和程序：本项目的主要目标是确定1)补充蛋白质和鱼油是否会改善胰岛素在体内的作用，并减少胰岛素敏感度降低的受试者的肌肉和肝脏脂肪堆积；以及2)补充氨基酸和鱼油是否会改善胰岛素在体内的作用，并减少胰岛素敏感度降低的受试者的肌肉和肝脏脂肪堆积。实验设计。参与者将在16周内每天服用营养补充剂。补充剂将以药丸和/或饮料的形式给予，并将包括：1)鱼蛋白，2)氨基酸，3)鱼蛋白+鱼油，或4)氨基酸+鱼油。第二天将进行不同的测试。这些测试包括通过身体X射线扫描(DEXA)测量身体成分，以及通过口服葡萄糖耐量试验(OGTT)测量胰岛素敏感性。意义：这项研究将有助于更好地了解糖尿病的原因以及如何预防糖尿病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Brief Background: In this study we will investigate if the accumulated fat in muscle and liver in people who already have a reduced effect of insulin (an important hormone for regulation of glucose and fat processing in the body), can be modified by intake of specific nutrients, e.g. fish oil and amino acids (building blocks of protein). Specific Aims and Procedures: The main goals of this project are to determine 1) if supplementation of protein and fish oil will improve the effect of insulin in the body and decrease muscle and liver fat accumulation in subjects with reduced sensitivity for insulin, and 2) if supplementation of amino acids and fish oil will improve the effect of insulin in the body and decrease muscle and liver fat accumulation in subjects with reduced sensitivity for insulin. Experimental Design. The participant will take a nutrient supplementation each day for 16 weeks. The supplementation will be given as pills and/or drinks and will consist of either: 1) fish protein, 2) amino acids, 3) fish protein + fish oil, or 4) amino acids + fish oil. The following day different tests will be performed. The tests include measurement of body composition by a body x-ray scan (DEXA), and test of the sensitivity for insulin measured by an oral glucose tolerance test (OGTT). Significance: The study will help to better understand the causes of diabetes and how diabetes can be prevented.