INSULIN RESISTANCE, AGING AND THEIR RELATION TO MUSCLE AND LIVER LIPID CONTENT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 与年龄相关的胰岛素抵抗的发展是文献中有充分记录的发现。此外，胰岛素抵抗的程度与肌肉和肝脏中细胞内脂质积累的程度之间存在关系。因此，我们建议确定胰岛素抵抗和衰老之间的关系，作为肌肉和肝脏脂质含量的函数在明显健康的个体。为此，我们将研究一组年轻人（18至35岁）和一组老年人（65岁以上）。 胰岛素抵抗的程度将根据涉及口服葡萄糖耐量试验的程序确定，而肌肉和肝脏脂质含量将使用质子磁共振光谱法确定。我们还计划研究一组老年2型糖尿病患者，他们将接受与健康人相同的测试程序。从后一组收集的数据将允许测试的假设，有共同的潜在因素与肌肉和肝脏的脂质含量之间的老化和2型糖尿病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The development of an age-related insulin resistance is a well-documented finding in the literature. Further, there is a relationship between the degree of insulin resistance and the extent of intracellular lipid accumulation in the muscle and liver. We, therefore, propose to determine the relationship between insulin resistance and aging as a function of muscle and liver lipid contents in apparently healthy individuals. For this purpose we will study a group of young (18 to 35 years of age) and a group of old (over 65 years of age) individuals. The extent of insulin resistance will be determined on the basis of procedures involving the oral glucose tolerance test, while muscle and liver lipid contents will be determined using proton magnetic resonance spectroscopy. We also plan to study a group of elderly individuals with type 2 diabetes mellitus who will undergo the same testing procedures as the healthy individuals. Data collected from the latter group will allow testing the hypothesis that there are common underlying factors related to muscle and liver lipid contents between aging and type 2 diabetes mellitus.