COBRE: OK MED RES FOUND: CORE IV: MRI IMAGING IN VIVO

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。MRI/MRS Core设备的总体目标是提供非侵入性体内监测能力，可用于评估大多数疾病发病进展阶段发生的形态学、生理、病理生理和代谢过程。MRI/MRS Core设施的一个主要重点是在实验性转基因小鼠或大鼠模型中研究心血管疾病的各个方面的体内发病机制。5个拟议项目中至少有3个将利用核磁共振/MRS核心设施作为主要组成部分，并从磁共振成像（MRI）和/或磁共振波谱（MRS）研究中显著受益。其余2个拟议项目可能会在未来拟议的体内项目中使用MRI和/或MRS技术。因此，MRI/MRS核心的建立至关重要，并且它与每个研究人员直接互动，分别针对拟议的项目，下文将进一步详细讨论。该核心将能够提供体内(1)形态学评估，提供任何心血管相关组织或血管的“微观”组织学信息，分辨率高达100米；(2)磁共振血管造影形式的血管特异性图像；(3)血管血流速度；(4)使用最新开发的血管特异性造影剂增强心血管发病机制的造影剂图像。(5)使用新开发的带有造影剂标记的单克隆抗体增强参与心血管疾病发病机制的特定内皮受体的图像；(6)与组织损伤或生物能量学变化相关的代谢过程。核磁共振/MRS核心设施将建立在位于贝尔大楼的新提议的俄克拉何马州医学研究基金会核磁共振/MRS设施中，由Rheal A. Towner博士指导。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The general objective of the MRI/MRS Core facility is to provide non-invasive in vivo monitoring capabilities that can be used to assess morphological, physiological, pathophysiological and metabolic processes that occur during progressive stages of the pathogenesis of most diseases. A major focus of the MRI/MRS Core facility is to study the in vivo pathogenesis of various aspects of cardiovascular diseases in experimental transgenic mice or rat models. At least three of the 5 proposed projects will utilize the MRI/MRS Core facility as a major component and significantly benefit from magnetic resonance imaging (MRI) and/or magnetic resonance spectroscopy (MRS) studies. The remaining 2 proposed projects will possibly use MRI and/or MRS techniques in future proposed in vivo projects. As a result it is of the utmost importance that the MRI/MRS Core is established and that it directly interacts with each of the researchers respective to the proposed projects as discussed in further detail below. The core will be able to specifically provide in vivo (1) morphological assessment that will provide "microscopic" histology information in any cardiovascular-associated tissue or vascular vessel up to 100 #m resolution, (2) vascular specific images in the form of magnetic resonance angiography, (3) vascular flow velocity, (4) contrast agent image enhancement of cardiovascular pathogenesis with the use of recently-developed vascular-specific contrast agents, (5) contrast agent image enhancement of specific endothelial receptors that are involved in the pathogenesis of a cardiovascular disease using newlydeveloped monoclonal antibodies tagged with a contrast agent, and (6) metabolic processes relating to changes in either tissue injury or bioenergetics. The MRI/MRS Core facility will be established in the newly-proposed Oklahoma Medical Research Foundation MRI/MRS Facility located in the Bell Building, under the direction of Dr. Rheal A. Towner.