Cell Migration Consortium

细胞迁移联盟

• 批准号: 6796503
• 负责人: ALAN F. Rick HORWITZ
• 金额: $ 47.54万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6796503
• 关键词: cell biology; cell migration; cooperative study; functional /structural genomics; imaging /visualization /scanning; informatics; molecular biology; protein structure function; proteins; proteomics

Migration is a pivotal process in many diverse phenomena including embryonic development, tumor formation and spread, leukocyte recruitment during immune responses, and wound repair. Elucidating the mechanisms underlying cell migration presents a formidable intellectual challenge since it is comprised of several complex molecular and cellular processes that must be coordinated in both space and time. A full comprehension of the process of cell migration requires an interdisciplinary approach that combines diverse specialists with skills to bring novel technical and intellectual solutions to the problem. While migration research is undergoing rapid growth in both investigators and knowledge, progress will soon by restrained by an approaching set of intellectual and technological barriers. We propose using the Large Scale Cooperative Project initiative to address the opportunities and overcome the challenges posed by the present barriers to progress in outstanding cell migration. At the center of the initiative is a plan to create a highly interactive, multi-disciplinary research Consortium comprised of Core Investigators with outstanding records of accomplishment in the field of adhesion and cell migration. At the center of the initiative is a plan to create a highly interactive, multi-disciplinary research Consortium comprised of Core Investigators with outstanding records of accomplishment in the field of adhesion and cell migration, collaborators who bring needed technology and expertise from other disciplines, e.g., mathematical modeling structure, imaging, biomaterials, and are supported to apply their expertise to the migration problem, and finally consultants, who provide advice and information on critical areas of research need to enhance the goals of the Consortium. A major objective of the Consortium is to develop new technologies that are needed to over come the barriers that face cell migration research. This will be accomplished by supporting five innovative, developmental research initiatives (designated "Development Cores") under the direction of the Core Investigators. The Proteomics and Genomics Core will determine the complete repertoire of genes and gene products that contribute to cell migration; the Structure Core will analyze the organization of large, supramolecular adhesive assemblies at the macro and atomic level, the Signaling Core will seek novel approaches to the detection of activated states of signaling molecules in space and time; the Transgenic and Knockout Core will create cells and mouse models with genetically altered migration machinery; the Modeling Core will develop quantitative assays and modeling mechanisms of component migratory processes and signal transduction through networks. In addition, the Consortium will support critical technologies and technology development through key Support Facilities, including mass spectrometry, biomaterials, protein production and analysis and cell imaging. Finally, the Consortium will provide infrastructure to support the administrative needs of the Consortium, promote interaction through video telecommunications, bioinformatics, data and information dissemination and the technology resources that are common to all of the Consortium projects.

迁移是许多不同现象的关键过程，包括胚胎发育、肿瘤形成和扩散、免疫反应中的白细胞募集和伤口修复。阐明细胞迁移的机制是一项艰巨的智力挑战，因为它由几个复杂的分子和细胞过程组成，必须在空间和时间上协调。对细胞迁移过程的全面理解需要跨学科的方法，将不同的专家与技能结合起来，为问题带来新颖的技术和智力解决方案。虽然移民研究在研究者和知识方面都在迅速增长，但进展很快就会受到一系列即将到来的智力和技术障碍的限制。我们建议使用大规模合作项目倡议来解决机遇并克服目前阻碍杰出细胞迁移进展的障碍所带来的挑战。该计划的核心是建立一个高度互动的多学科研究联盟，由在粘附和细胞迁移领域有杰出成就的核心研究人员组成。该计划的核心是建立一个高度互动的多学科研究联盟，该联盟由在粘附和细胞迁移领域有杰出成就的核心研究者组成，合作者从其他学科（如数学建模结构、成像、生物材料）带来所需的技术和专业知识，并支持将他们的专业知识应用于迁移问题，最后是顾问。他们在关键的研究领域提供建议和信息，以加强联盟的目标。该联盟的一个主要目标是开发克服细胞迁移研究所面临的障碍所需的新技术。这将通过在核心调查员的指导下支持五项创新的发展研究计划（称为“发展核心”）来实现。蛋白质组学和基因组学核心将确定有助于细胞迁移的基因和基因产物的完整库；结构核心将在宏观和原子水平上分析大型超分子粘合剂组件的组织，信号核心将寻求在空间和时间上检测信号分子激活状态的新方法；转基因和敲除核心将创造具有基因改变迁移机制的细胞和小鼠模型；建模核心将通过网络开发定量分析和组件迁移过程和信号转导的建模机制。此外，该联盟将通过关键支持设施支持关键技术和技术开发，包括质谱、生物材料、蛋白质生产和分析以及细胞成像。最后，该联盟将提供基础设施以支持该联盟的行政需要，通过视频电信、生物信息学、数据和信息传播以及所有联盟项目共有的技术资源促进相互作用。