California NeuroAIDS Tissue Network (CNTN)

描述(由申请人提供)：本申请续期加州神经艾滋病组织网络(CNTN)响应RFA-MH-08-021。CNTN是国家神经艾滋病组织联盟(NNTC)的一部分，该联盟包括在Mt.加州大学洛杉矶分校西奈医学院和德克萨斯大学加尔维斯顿分校。与RFA的要求一致，本申请分为两部分：A部分(对所有4项申请相同)描述了NNTC的总体目标和运作，包括共同的协议和共同的科学议程。B部分是站点特定的应用程序，如下所述。CNTN的主要目标是对艾滋病毒携带者进行仔细的神经医学、神经精神病学和实验室评估，以便这些数据可以与从因研究和同意器官捐赠而死亡的参与者的大脑和其他组织获得的神经病理信息联系起来。这使我们能够通过向研究人员提供组织、液体和数据来支持全国各地的研究，这些组织、液体和数据将使他们能够回答有关艾滋病神经系统疾病的原因以及可能的治疗和预防的关键问题。到目前为止，CNTN拥有544名艾滋病毒携带者的生前临床信息，并分析了198名艾滋病毒感染者的脑和其他组织。我们还储存了20名未感染艾滋病毒的人的组织，用于 比较研究。作为NNTC的积极成员，CNTN向NNTC协调办公室提供数据，使NNTC能够回应来自各种调查人员的212项请求。 在这一继续阶段，CNTN计划通过科学议程增加其资源任务，如 在RFA中设想的。初步的科学分析将集中在免疫的神经病理特征上 重组炎症综合征，探索艾滋病毒白质脑病的细胞基础和结构相关性，长期暴露于艾滋病毒和抗逆转录病毒治疗的人中早期神经元老化的机制，以及病毒耐药性在艾滋病毒脑病中的作用。我们对NNTC的资源贡献将包括成为NNTC科学领导小组的成员，在NNTC范围内的初步研究和QA活动上的合作，在CNTN专业领域的技术援助，以及来自生前和死后评估的数据的持续贡献。 A部分：

DESCRIPTION (provided by applicant): This application for renewal of the California NeuroAIDS Tissue Network (CNTN) responds to RFA-MH-08-021. The CNTN is part of the National NeuroAIDS Tissue Consortium (NNTC) which includes sites at the Mt. Sinai School of Medicine, UCLA, and University of Texas Galveston. Consistent with the RFA's requirements, this application is in two parts: Part A (identical for all 4 applications) describes the overall aims and operations of the NNTC, including common protocols and shared scientific agendas. Part B is the Site specific application, which is described below. The CNTN's main objective has been to perform careful neuromedical, neuropsychiatric, and laboratory evaluations of persons with HIV so that these data can be linked to neuropathological information obtained from brain and other tissues of participants who die on study and consent to organ donation. This enables us to support research throughout the country by providing investigators with tissues, fluids, and data that will keep them to answer critical questions on the causes and possible treatment and prevention of neurologic disease in AIDS. To date CNTN has antemortem clinical information on 544 persons living with HIV and have analyzed brain and other tissues from 198 HIV+ persons. We have also banked tissues from 20 HIV uninfected persons for comparison study. As an active member of the NNTC, CNTN contributes data to the NNTC Coordinating Office, which has enabled NNTC to respond to 212 requests from various investigators. In this continuation phase CNTN plans to augment its resource mission with a scientific agenda, as envisioned in the RFA. Initial scientific analyses will focus on neuropathologic characteristics of immune reconstitution inflammatory syndrome, an exploration of the cellular basis and structural correlates of HIV leukoencephalopathy, mechanisms of early neuronal aging among persons with prolonged exposure to HIV and ARV treatment, and the role of viral drug resistance in HIV brain disease. Our resource contributions to the NNTC will include membership in the NNTC's Scientific Leadership Group, collaboration on NNTC-wide preliminary studies and QA activities, technical assistance in areas of CNTN's expertise, and continuing contribution of data from antemortem and postmortem evaluations. Part A: