ION TRAP for NJC

描述(由申请人提供)：此申请是为了在国家犹太医学研究中心(NJMRC)进行蛋白质组学实验而设计的LC/MS/MS离子陷阱质谱仪。NJMRC在患者护理和生物医学研究方面享有国际声誉，连续九年被《美国新闻和世界报道》评为美国排名第一的呼吸医院。国家犹太人自2004年以来一直缺乏以研究为基础的质谱学设施，也从未有过正式的蛋白质组学计划；这项技术是20多名研究人员研究的重要组成部分，他们的长期成功依赖于质谱学。我们的目标是为我们的研究人员提供共享的质谱学资源，以支持目前和拟议的由NIH资助的生物医学研究，NJMRC已为此投入了大量资源。这项建议将具体展示以下部分：1)对离子陷阱质谱仪的充分、合理的需求，2)操作和监督该仪器的现有专业知识，3)显著加强NIH资助的研究项目，4)实际的财务和管理计划，以及5)强有力的机构承诺。新开发的质谱学设备将满足我们NIH资助的研究人员对最先进技术的巨大需求，以及对创新试点研究和临床诊断发展的巨大需求。所要求的离子捕捉器将是该设施的重要组成部分。作为一个高度专注的机构，我们相信NJMRC准备在呼吸医学方面提供创新的、高影响的研究。这只有在我们的调查人员获得尖端技术的情况下才能实现。相关性：成功的申请将通过支持NJMRC目前从事生物医学和临床研究的个人的研究努力，对公共卫生产生重大影响。该仪器将用于支持当前和拟议的临床和非临床研究，在这些研究中，有可能发现生物标记物，确定药物靶标，并提高我们对几种疾病基本机制的总体了解。

DESCRIPTION (provided by applicant): This application is for an LC/MS/MS ion trap mass spectrometer for the purpose of performing proteomics experiments at the National Jewish Medical Research Center (NJMRC). NJMRC has an international reputation for patient care and biomedical research and has been ranked the #1 Respiratory Hospital in the United States by US News and World Report for nine consecutive years. National Jewish has lacked a research-based mass spectrometry facility since 2004 and has never had a formal proteomics program; this technology is an essential component of research for over 20 investigators whose long-term success is dependent on mass spectrometry. Our objective is to provide our investigators with a shared mass spectrometry resource to support current and proposed NIH-funded biomedical research and NJMRC has committed substantial resources towards this end. This proposal will specifically demonstrate the following components: 1) a substantial, justified need for an ion trap mass spectrometer, 2) existing expertise to operate and oversee the instrument, 3) significant enhancement of NIH-funded research projects, 4) a practical financial and management plan, and 5) a strong institutional commitment. The newly developed mass spectrometry facility will address the tremendous demand for state-of-the-art technologies by our NIH-funded researchers as well as for innovative pilot studies and towards the development of clinical diagnostics. The requested ion trap will be an essential component of this facility. As a highly focused institution, we believe that NJMRC is poised to deliver innovative, high-impact studies in respiratory medicine. This can only be achieved if cutting edge technologies are available to our investigators. Relevance: A successful application will have a significant impact on public health through supporting research efforts of individuals at NJMRC who are currently engaged in biomedical and clinical research. The instrument will be used to support current and proposed clinical and non-clinical studies where there is the potential for biomarker discovery, identifying drug targets, and improving our overall knowledge of the basic mechanisms of several diseases.