ION TRAP for NJC

描述（由申请人提供）：本申请是用于在国家犹太医学研究中心（NJMRC）进行蛋白质组学实验的LC/MS/MS离子阱质谱仪。NJMRC在患者护理和生物医学研究方面享有国际声誉，连续九年被《美国新闻与世界报道》评为美国呼吸系统医院第一名。自2004年以来，国家犹太人一直缺乏以研究为基础的质谱分析设施，从未有过正式的蛋白质组学计划；这项技术是20多名研究人员研究的重要组成部分，他们的长期成功依赖于质谱分析。我们的目标是为我们的研究人员提供共享的质谱资源，以支持当前和拟议的nih资助的生物医学研究，NJMRC为此目的投入了大量资源。该提案将具体展示以下组成部分：1)对离子阱质谱仪的大量合理需求，2)操作和监督仪器的现有专业知识，3)nih资助的研究项目的显著增强，4)实际的财务和管理计划，5)强有力的机构承诺。新开发的质谱设备将满足美国国立卫生研究院资助的研究人员对最先进技术的巨大需求，以及创新的试点研究和临床诊断的发展。所要求的离子阱将是该设施的重要组成部分。作为一个高度专注的机构，我们相信NJMRC将在呼吸医学领域提供创新的、高影响力的研究。这只有在我们的调查人员能够获得尖端技术的情况下才能实现。相关性：通过支持NJMRC目前从事生物医学和临床研究的个人的研究工作，成功的申请将对公共卫生产生重大影响。该仪器将用于支持当前和拟议的临床和非临床研究，这些研究有可能发现生物标志物，确定药物靶点，并提高我们对几种疾病基本机制的总体认识。

DESCRIPTION (provided by applicant): This application is for an LC/MS/MS ion trap mass spectrometer for the purpose of performing proteomics experiments at the National Jewish Medical Research Center (NJMRC). NJMRC has an international reputation for patient care and biomedical research and has been ranked the #1 Respiratory Hospital in the United States by US News and World Report for nine consecutive years. National Jewish has lacked a research-based mass spectrometry facility since 2004 and has never had a formal proteomics program; this technology is an essential component of research for over 20 investigators whose long-term success is dependent on mass spectrometry. Our objective is to provide our investigators with a shared mass spectrometry resource to support current and proposed NIH-funded biomedical research and NJMRC has committed substantial resources towards this end. This proposal will specifically demonstrate the following components: 1) a substantial, justified need for an ion trap mass spectrometer, 2) existing expertise to operate and oversee the instrument, 3) significant enhancement of NIH-funded research projects, 4) a practical financial and management plan, and 5) a strong institutional commitment. The newly developed mass spectrometry facility will address the tremendous demand for state-of-the-art technologies by our NIH-funded researchers as well as for innovative pilot studies and towards the development of clinical diagnostics. The requested ion trap will be an essential component of this facility. As a highly focused institution, we believe that NJMRC is poised to deliver innovative, high-impact studies in respiratory medicine. This can only be achieved if cutting edge technologies are available to our investigators. Relevance: A successful application will have a significant impact on public health through supporting research efforts of individuals at NJMRC who are currently engaged in biomedical and clinical research. The instrument will be used to support current and proposed clinical and non-clinical studies where there is the potential for biomarker discovery, identifying drug targets, and improving our overall knowledge of the basic mechanisms of several diseases.