Biomarkers of Insufficient Sleep and Sleepiness

 描述（由申请人提供）：睡眠和觉醒障碍影响5000万至7000万美国人，睡眠不足是流行病，超过50%的美国人报告每晚睡眠不足7小时。与睡眠不足相关的健康问题包括炎症、抑郁和焦虑、糖尿病、压力、药物滥用、生活质量差、肥胖和工作/驾驶时与疲劳相关的事故。虽然睡眠对整体健康，幸福和公共安全的贡献是公认的，但还没有建立睡眠不足的临床生物标志物。这样的生物标志物将具有作为困倦的路边生物标志物的效用（例如，困倦驾驶），监控工作疲劳/适合工作（例如，运输、军事行动卫生保健）、监测睡眠健康以及用于临床诊断和临床测量。 治疗结果。因此，我们设计了一个受控的实验室睡眠不足的协议，利用代谢组学，以确定睡眠不足的生物标志物。我们现有的R 01“睡眠丧失的代谢和认知后果”获得的NIH行政补充的初步代谢组学数据为这项提议奠定了基础，并促进了我们提出的发现和有针对性的方法。目前的提案是对2014年睡眠研究学会和美国睡眠医学学会联合工作组报告的关键目标的回应。我们建议确定在睡眠不足期间持续发生的代谢物变化。我们还将针对我们以前的研究工作确定的代谢物作为潜在的生物标志物。作为一个探索性的结果，我们将检查相关的代谢物和认知能力的变化，在睡眠不足。这些建议的结果支持NIH精准医学计划和2011年NIH睡眠障碍研究计划，以确定睡眠不足的生物标志物，并在交叉领域进行睡眠和昼夜节律研究培训，以加快发现和转化的步伐。

 DESCRIPTION (provided by applicant): Sleep and wakefulness disorders impact 50 to 70 million Americans and insufficient sleep is epidemic with over 50% of Americans reporting less than 7 hours of sleep per night. Health problems associated with insufficient sleep include inflammation, depression and anxiety, diabetes, stress, drug abuse, poor quality of life, obesity, and fatigue related accidents on the job/while driving. While the contribution of sleep to overall health, well-being, and public safety is recognized, no established clinical biomarkers of sleep deficiency exist. Such biomarkers would have utility as road-side biomarkers of sleepiness (e.g., drowsy driving), monitoring on the job fatigue/fitness for duty (e.g., transportation, military ops health care), monitoring sleep health, as well as for clinical diagnostics and measures of clinical treatment outcomes. Thus, we designed a controlled laboratory insufficient sleep protocol utilizing metabolomics to identify biomarkers of insufficient sleep. Preliminary metabolomics data from our NIH Administrative Supplement awarded to our existing R01 "Metabolic and Cognitive Consequences of Sleep Loss" set the stage for this proposal and facilitated our proposed discovery and targeted approaches. The current proposal is responsive to key goals of the 2014 Joint Task Force of the Sleep Research Society and American Academy of Sleep Medicine report. We propose to identify changes in metabolites that consistently occur during insufficient sleep. We will also target metabolites identified by our previous research efforts as potential biomarkers. As an exploratory outcome we will examine associated changes in metabolites and cognitive performance during insufficient sleep. These proposed outcomes support the NIH Precision Medicine Initiative and the 2011 NIH Sleep Disorders Research Plan to identify biomarkers of sleep deficiency and enabling sleep and circadian research training in cross-cutting domains to accelerate the pace of discovery and translation.