NEUROPHYSIOLOGICAL CONSEQUENCES OF LUMBAR FACET MOVEMENT

描述：（申请人的摘要）本发明的第一个长期目标是： 项目是了解神经生理机制，有助于 腰椎功能;第二是了解机制， 哪种脊柱推拿会影响腰痛 背痛是很常见的 在我们的社会中，卫生与公众服务部最近 推荐脊柱推拿作为一种治疗方法。 拟议 研究的前提是， 对椎关节运动的反应将为 了解导致腰痛的感觉机制， 物理治疗有助于缓解背痛的机制。 的 提出的实验使用系统的方法来确定放电 腰椎运动诱发的腰椎感觉神经元特性 面。 神经生理学研究将在单个识别的 感觉神经元来测试以下假设：1） 腰椎中的I、II、III和IV组传入神经用 小关节运动的大小和方向; 2） 第三组和第四组传入神经支配肌肉和深部组织， 腰椎在小关节运动时肌肉疲劳增强 诱导代谢产物，包括钾、乳酸和双质子化 磷酸盐;和3）这些传入神经的放电也被增强， 炎症介质，包括缓激肽、血清素、PGE 2和PGI 2。

DESCRIPTION: (Applicant's abstract) The first long range goal of this project is to understand the neurophysiological mechanisms that contribute to lumbar spine function; the second is to understand the mechanisms by which spinal manipulation affects low back pain. Back pain is very common in our society, and the Department of Health and Human Services recently recommended spinal manipulation as one treatment. The proposed investigation is based on the premise that understanding the neural responses to vertebral joint movement will provide a rational basis for understanding sensory mechanisms contributing to low back pain and the mechanisms by which physical treatment helps relieve back pain. The experiments proposed use a systematic approach to determine the discharge characteristics of lumbar sensory neurons evoked by movement of the lumbar facets. Neurophysiological studies will be performed on single identified sensory neurons to test the following hypotheses: 1) that the discharges of group I, II, III and IV afferents in the lumbar spine are graded with the magnitude and direction of facet joint movement; 2) that the discharges of group III and IV afferents innervating muscles and deep tissues of the lumbar spine during facet joint movement are enhanced by muscle-fatigue induced metabolites, including potassium, lactic acid and diprotonated phosphate; and 3) that the discharges of these afferents is also enhanced by inflammatory mediators, including bradykinin, serotonin, PGE2 and PGI2.