NEUROPHYSIOLOGICAL CONSEQUENCES OF LUMBAR FACET MOVEMENT

描述：(申请人摘要)这项计划的第一个远景目标 这个项目是为了了解神经生理机制 对腰椎功能的影响；二是通过 哪种脊椎手法会影响下腰痛。背痛是很常见的 在我们的社会中，以及卫生和公众服务部最近 建议将脊椎手法作为一种治疗方法。建议数 调查是基于这样的前提：了解神经 对脊椎关节运动的反应将提供合理的依据 了解导致下腰痛的感觉机制和 物理治疗有助于缓解背部疼痛的机制。这个 建议的实验使用系统的方法来确定排放 腰椎运动诱发的腰椎感觉神经元特征 小平面。神经生理学研究将在单个被识别的 以检验以下假设：1)感觉神经元的放电 腰椎I、II、III和IV组传入神经按 小关节运动的大小和方向；2)小关节的放电 第III和IV组传入神经支配大鼠的肌肉和深部组织。 小关节运动中的腰椎因肌肉疲劳而增强 诱导代谢产物，包括钾、乳酸和二质子化 磷酸盐；以及3)这些传入物质的放电也因 炎症介质，包括缓激肽、5-羟色胺、前列腺素E_2和前列环素。

DESCRIPTION: (Applicant's abstract) The first long range goal of this project is to understand the neurophysiological mechanisms that contribute to lumbar spine function; the second is to understand the mechanisms by which spinal manipulation affects low back pain. Back pain is very common in our society, and the Department of Health and Human Services recently recommended spinal manipulation as one treatment. The proposed investigation is based on the premise that understanding the neural responses to vertebral joint movement will provide a rational basis for understanding sensory mechanisms contributing to low back pain and the mechanisms by which physical treatment helps relieve back pain. The experiments proposed use a systematic approach to determine the discharge characteristics of lumbar sensory neurons evoked by movement of the lumbar facets. Neurophysiological studies will be performed on single identified sensory neurons to test the following hypotheses: 1) that the discharges of group I, II, III and IV afferents in the lumbar spine are graded with the magnitude and direction of facet joint movement; 2) that the discharges of group III and IV afferents innervating muscles and deep tissues of the lumbar spine during facet joint movement are enhanced by muscle-fatigue induced metabolites, including potassium, lactic acid and diprotonated phosphate; and 3) that the discharges of these afferents is also enhanced by inflammatory mediators, including bradykinin, serotonin, PGE2 and PGI2.