IC/PBS Phenotypes in a Community Sample of Female Twins

女性双胞胎社区样本中的 IC/PBS 表型

• 批准号: 7570943
• 负责人: DEDRA S BUCHWALD
• 金额: $ 25.73万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7570943
• 关键词: Address; Anxiety; Basic Science; Behavioral; Biological; Brain; Characteristics; Chronic Fatigue Syndrome; Chronic Prostatitis; Clinical; Communities; Complement; Condition; Controlled Study; Data; Depth; Disease; Dizygotic Twins; Environment; Environmental Risk Factor; Epidemiology; Etiology; Evaluation; Exhibits; Female; Fibromyalgia; Functional Magnetic Resonance Imaging; Functional disorder; Future; Genetic; Genotype; HPSE gene; Hydrocortisone; Interstitial Cystitis; Investigation; Irritable Bowel Syndrome; Knowledge; Link; Measures; Modeling; Monozygotic Twinning; Monozygotic twins; Neurobiology; Neurosecretory Systems; Pain; Pain-Free; Phenotype; Physiological; Play; Population; Positioning Attribute; Post-Traumatic Stress Disorders; Questionnaires; Registries; Relative (related person); Reporting; Research; Research Design; Research Priority; Risk Factors; Role; Salivary; Sampling; Specimen; Staging; Surveys; Symptoms; Syndrome; Systems Biology; Testing; Translational Research; Twin Multiple Birth; Twin Studies; Universities; Up-Regulation; Washington; base; body system; central sensitization; chronic pain; chronic pelvic pain; cohort; depressive symptoms; design; disease phenotype; experience; functional status; hypothalamic-pituitary-adrenal axis; interdisciplinary approach; member; neuroimaging; novel; painful bladder syndrome; psychosocial; relating to nervous system; tertiary care; urologic

This study is positioned to identify and characterize the pathological and physiological factors associated with IC/PBS and their relationship with RCPS. It offers a novel opportunity to examine the genetic and common environmental contributions to IC/PBS phenotypes. Our multidisciplinary approach will expand knowledge of the underlying genetic, environmental, and neurobiological factors that promote IC/PBS and its primary symptom of pain. One major strength of this project is that it addresses all 3 MAPP RFA Research Priorities. Our primary objective is to comprehensively investigate UCPPS disease phenotypes. As we examine the demographic characteristics, IC/PBS symptoms, clinical features (e.g., symptoms of FM, IBS, and CFS), psychiatric symptoms, and psychosocial and functional status in Stage 1, we also will address the epidemiology of IC/PBS. In Stage 2 we conduct a deep phenotyping investigation of the IC/PBS physical/anatomical and physiological characteristics. An important aspect of these studies is the identification and characterization of pathological and physiological associations between IC/PBS and related RCPS, such as FM and CFS. Stage 2's emphasis on pathophysiology in a uniquely valuable small cohort, incorporates a basic/translational science component. Specifically, we will collect specimens to examine neural upregulation manifested as urothelial dysfunction for Project 3 (an organ-system approach) to complement our assessment of central sensitization and the HPA axis changes (a systemic approach).

本研究定位于识别和表征病理和生理因素 与IC/PBS的相关性及其与RCPS的关系。它提供了一个新的机会来检查基因 和IC/PBS表型的共同环境贡献。我们的多学科方法将扩大 知识的潜在遗传，环境和神经生物学因素，促进IC/PBS及其 疼痛的主要症状。该项目的一个主要优势是它解决了所有3个MAPP RFA研究 优先事项我们的主要目标是全面调查UCPPS疾病表型。正如我们 检查人口统计学特征、IC/PBS症状、临床特征（例如，症状FM，IBS，和 CFS），精神症状，以及心理社会和功能状态，我们还将在第1阶段讨论 IC/PBS的流行病学。在第2阶段，我们对IC/PBS进行了深入的表型研究。 物理/解剖和生理特征。这些研究的一个重要方面是识别 以及IC/PBS和相关RCPS之间的病理和生理关联的表征， FM和CFS。第2阶段的重点是病理生理学在一个独特的有价值的小队列，包括一个 基础/转化科学部分。具体来说，我们将收集标本， 表现为尿路上皮功能障碍的项目3（器官系统方法），以补充我们的评估 中枢致敏和HPA轴变化（系统方法）。