Interdisciplinary network: Mathematical Models and Experimental Microbial Systems: Tools for Studying Evolution

跨学科网络：数学模型和实验微生物系统：研究进化的工具

• 批准号: EP/F037856/1
• 负责人: Nicholas Britton
• 金额: $ 8.21万
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF037856%2F1
• 关键词: Interdisciplinary; network; Mathematical; Models; Experimental

In June 2007 we held a workshop entitled Mathematical Models and Experimental Microbial system: Tools for Studying Evolution as a precursor to forming a network in this area. The workshop was a huge success and we request funding to form a follow-on network as the essential next step to allow the fledgling interactions to flourish and to bridge gaps and forge links that will lead to new research directions and long term collaborations.The proposed network will bring together mathematicians and life scientists to jointly work on some of the major problems in evolutionary ecology inspired by two fundamental questions: What determines species diversity? and How did cooperative behaviour evolve?. These questions were highlighted in a recent special issue of Science from among 25 key problems that face the scientific community over the coming decades that make the timing of this network particularly apposite.An increasingly fruitful approach to studying evolutionary problems is to perform laboratory experiments on microorganisms such as bacteria, viruses, yeast and some slime-moulds where evolution can be observed as it happens and where high-quality data can be obtained at molecular, genetic, metabolic and cellular levels, data that is absolutely essential to the modelling process. This has lead to a revolution in microbial ecology and a recent article in Nature Microbiology has emphasized that the full potential of the ongoing revolution will not be realised if research is not directed and driven by theory and that the generality of established theory must be tested using microbial experiments.Therefore our network will bring together a range of scientists from mathematicians, theoretical modellers, experimental microbial ecologists, microbiologists to biochemists. Their expertise will allow us to formulate and tackle complex evolutionary problems at many different levels, from multi-trophic, through to population and down to the cellular level. We will hold four workshops culminating in the final international meeting at the end of the thee-year support period. The day-to-day contact amongst the network members will be maintained through the network web-site and we will also hold a summer school in the second your of the grant. The EPSRC support will allow us to set up a solid foundation for the growth and expansion of the network culminating in the world-leading and self-sustainable virtual centre for studying evolution.

2007年6月，我们举办了一个题为“数学模型和实验微生物系统：研究进化的工具”的研讨会，作为在这一领域形成网络的先驱。这次研讨会取得了巨大的成功，我们申请资金来建立一个后续网络，作为重要的下一步，让羽翼未丰的相互作用蓬勃发展，弥合差距，建立联系，这将导致新的研究方向和长期合作。拟议的网络将汇集数学家和生命科学家，共同研究进化生态学中的一些主要问题，这些问题受到两个基本问题的启发：是什么决定了物种的多样性？合作行为是如何进化的？这些问题在最近一期《科学》特刊中得到了强调，这些问题是科学界在未来几十年中面临的25个关键问题之一，这使得这个网络的时机特别合适。研究进化问题的一种越来越富有成效的方法是对细菌，病毒，酵母菌和一些黏菌，在那里可以观察到进化的发生，可以在分子、遗传、代谢和细胞水平上获得高质量的数据，这些数据对建模过程绝对必要。这导致了微生物生态学的革命，最近在《自然微生物学》上的一篇文章强调，如果研究不是由理论指导和驱动，那么正在进行的革命的全部潜力将无法实现，并且必须使用微生物实验来测试已建立的理论的普遍性。因此，我们的网络将汇集一系列科学家，从数学家，理论建模者，实验微生物生态学家，微生物学家到生物化学家他们的专业知识将使我们能够制定和解决复杂的进化问题在许多不同的水平，从多营养，通过人口和下降到细胞水平。我们将举办四次研讨会，最终在三年支持期结束时举行最后一次国际会议。网络成员之间的日常联系将通过网络网站保持，我们还将在赠款的第二年举办暑期学校。EPSRC的支持将使我们能够为网络的增长和扩展奠定坚实的基础，最终成为世界领先和自我可持续的虚拟中心，用于研究进化。

项目成果

Molecular and evolutionary bases of within-patient genotypic and phenotypic diversity in Escherichia coli extraintestinal infections.

• DOI: 10.1371/journal.ppat.1001125
• 发表时间: 2010-09-30
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Levert M;Zamfir O;Clermont O;Bouvet O;Lespinats S;Hipeaux MC;Branger C;Picard B;Saint-Ruf C;Norel F;Balliau T;Zivy M;Le Nagard H;Cruveiller S;Chane-Woon-Ming B;Nilsson S;Gudelj I;Phan K;Ferenci T;Tenaillon O;Denamur E
• 通讯作者: Denamur E

Single-cell time-lapse analysis of depletion of the universally conserved essential protein YgjD

• DOI: 10.1186/1471-2180-11-118
• 发表时间: 2011-05-27
• 期刊: BMC MICROBIOLOGY
• 影响因子: 4.2
• 作者: Bergmiller, Tobias;Pena-Miller, Rafael;Ackermann, Martin
• 通讯作者: Ackermann, Martin