Ligand Recognition & Molecular Gating 2008 Gordon Research Conference

描述（由申请人提供）：本提案要求部分支持将于2008年3月2日至7日在加利福尼亚州文图拉举行的戈登研究会议系列的配体识别和分子门控国际会议。会议的广泛和长期目标是增加我们对膜蛋白如何结合配体（离子，小分子，蛋白质）和跨膜传输信号的理解。会议重点关注离子通道，G蛋白偶联受体和所有类型的转运蛋白，重点是将高分辨率结构数据与功能和理论数据相结合，以探测这些蛋白质配体的门控或激活。本次会议的具体目标将是召集约40名发言人，代表膜蛋白研究的关键领域，共有150名与会者参加为期五天的会议。该计划将有一个主题演讲和八个会议，广泛讨论核苷酸偶联转运蛋白;离子，小分子和糖的转运蛋白;配体和电压门控离子通道，G蛋白偶联受体中的配体识别;脂质对蛋白质折叠和功能的影响;以及获得膜蛋白结构信息的新方法。该应用程序的意义在于，戈登研究会议配体识别和分子门控是一系列会议的关键组成部分，这些会议推动了膜蛋白结构/功能研究人员国际社会的研究。该应用的健康相关性在于，目前超过50%的药物靶点是本次会议上讨论的类型的整合膜蛋白，其结构和功能描述与新化疗药物的设计直接相关。生物化学家、生物药理学家、结构生物学家和理论家之间的新结果的介绍和讨论将定义该领域需要实验解决的问题，影响诸如癌症（ABC转运蛋白）、视力/抑郁/心血管疾病（G蛋白偶联受体）和神经疾病（离子通道）等领域。公共卫生相关性：该应用的健康相关性在于，目前超过50%的药物靶点是本次会议上讨论的类型的整合膜蛋白，其结构和功能描述与新化疗药物的设计直接相关。生物化学家，生物药理学家，结构生物学家和理论家之间的新结果的介绍和讨论将定义该领域需要实验解决的问题，影响癌症（ABC转运蛋白），视力/抑郁症/心血管疾病（G蛋白偶联受体）和神经疾病（离子通道）等领域。

DESCRIPTION (provided by applicant): This proposal requests partial support for an international meeting on Ligand Recognition and Molecular Gating as part of the Gordon Research Conference series to be held in Ventura, CA, March 2-7, 2008. The broad and long term goal of the conference is to increase our understanding of how integral membrane proteins bind ligands (ions, small molecules, proteins) and transmit signals across membranes. The conference focuses on ion channels, G-protein coupled receptors, and transporters of all types, with emphasis on combining high resolution structural data with functional and theoretical data to probe gating or activation by ligands of these proteins. The specific aims of this meeting will be to convene approximately 40 speakers that represent critical areas of membrane protein research with a total of 150 participants for a five day conference in a relatively isolated setting. The program will have a keynote address and eight sessions that broadly address nucleotide-coupled transporters; transporters of ions, small molecules and sugars; ligand- and voltage-gated ion channels, ligand recognition in G-protein coupled receptors; the influence of lipids on protein folding and function; and new methods for obtaining structural information on membrane proteins. The significance of this application is that the Gordon Research Conference on Ligand Recognition and Molecular Gating is a critical component of the series of conferences that drive research in the international community of membrane protein structure/function researchers. The health relatedness of this application is that well over 50% of current pharmaceutical targets are integral membrane proteins of the types discussed at this conference, with structural and functional descriptions directly relevant to the design of new chemotherapeutic agents. The presentation and discussion of new results among biochemists, biophysicists, structural biologists, and theoreticians will define the questions that require experimental resolution in this field, impacting areas such as cancer (ABC transporters), vision/depression/cardiovascular diseases (G- protein coupled receptors), and neurological diseases (ion channels). PUBLIC HEALTH RELEVANCE: The health relatedness of this application is that well over 50% of current pharmaceutical targets are integral membrane proteins of the types discussed at this conference, with structural and functional descriptions directly relevant to the design of new chemotherapeutic agents. The presentation and discussion of new results among biochemists, biophysicists, structural biologists, and theoreticians will define the questions that require experimental resolution in this field, impacting areas such as cancer (ABC transporters), vision/ depression/ cardiovascular diseases (G-protein coupled receptors), and neurological diseases (ion channels).