2010 Ligand Recognition and Molecular Gating Gordon Research Conference

描述(申请人提供)：配基识别和分子门控戈登研究会议将于2010年5月16-21日在意大利Il Ciocco举行。会议的广泛和长期目标是增加我们对完整的膜蛋白如何结合配体(离子、小分子、蛋白质)和跨膜传递信号的理解。会议的主要目的是分享关于离子通道、G蛋白偶联受体和所有类型的转运蛋白的最新知识，重点是将高分辨率结构数据与功能和理论数据相结合，以探索这些蛋白质的门控或由配体激活。在这三类不同的膜蛋白中，一个统一的主题是配体结合、门控和/或运输涉及构象变化。确定的、与机械相关的全功能蛋白质构象的特征将是2010年会议的一个重点。该项目将有40名演讲者、膜蛋白研究领域的知名领导者以及有前途的年轻研究人员。一场主题演讲和八场会议将广泛讨论次级转运蛋白的结构和机制，配体门控和电压门控离子通道，细胞间通讯通道，通过外膜的通道，膜-蛋白质脂相互作用，探测膜蛋白结构和构象的新方法，以及G蛋白偶联受体的激活和与G蛋白和配体的相互作用。关于配基识别和分子门控的戈登研究会议是推动国际膜蛋白质结构/功能研究人员研究的一系列会议的重要组成部分。这一应用的与健康相关的是，目前超过50%的药物靶标是本次会议讨论的类型的完整膜蛋白，其结构和功能描述与新化疗药物的设计直接相关。影响范围从癌症(ABC转运蛋白)、视力/抑郁/心血管疾病(G蛋白偶联受体)、神经退行性疾病、皮肤病、耳聋和发育异常(连接蛋白)到神经疾病(离子通道)。 公共卫生相关性：这一应用的健康相关性是，目前超过50%的药物靶标是本次会议讨论的类型的完整膜蛋白。了解这些膜结合分子的结构和功能是21世纪最重要的目标之一，无论是对科学还是对新疗法的开发。讨论的结果和设计的新实验对癌症(ABC转运蛋白)、视力/抑郁/心血管疾病(G蛋白偶联受体)、神经退行性疾病、皮肤病、耳聋和发育异常(连接蛋白)到神经疾病(离子通道)等领域产生了影响。

DESCRIPTION (provided by applicant): The Gordon Research Conference on Ligand Recognition and Molecular Gating will be held on May 16 - 21, 2010 in Il Ciocco, Italy. The broad and long term goal of the conference is to increase our understanding of how integral membrane proteins bind ligands (ions, small molecules, proteins) and transmit signals across membranes. The conference main objective is to share the newest knowledge on ion channels, G- protein coupled receptors, and transporters of all types, with emphasis on combining high resolution structural data with functional and theoretical data to probe gating or activation by ligands of these proteins. A unifying theme in these three different classes of membrane proteins is that ligand binding, gating, and/or transport involves conformational changes. The characterization of defined, mechanistically relevant conformations of fully functional protein will be a focus of the 2010 conference. The program will have 40 speakers, well-established leaders in the field of membrane protein research as well as promising young investigators. A keynote presentation and eight sessions will broadly address structure and mechanism of secondary transporters, ligand-gated and voltage-gated ion channels, channels of intercellular communication, passages through the outer membrane, membrane-protein lipid interactions, new methods probing membrane protein structures and conformations, and G-protein coupled receptor activation and interaction with G proteins and ligands. The Gordon Research Conference on Ligand Recognition and Molecular Gating is a critical component of the series of conferences that drive research in the international community of membrane protein structure/function researchers. The health relatedness of this application is that well over 50% of current pharmaceutical targets are integral membrane proteins of the types discussed at this conference, with structural and functional descriptions directly relevant to the design of new chemotherapeutic agents. The impact areas range from cancer (ABC transporters), vision/ depression/cardiovascular diseases (G-protein coupled receptors), neurodegenerative diseases, skin diseases, deafness, and developmental abnormalities (connexins) to neurological diseases (ion channels). PUBLIC HEALTH RELEVANCE: The health relatedness of this application is that well over 50% of current pharmaceutical targets are integral membrane proteins of the types discussed at this conference. Understanding the structure and function of these membrane bound molecules is one of the most important goals of the 21st century, both for science and for development of new therapeutics. Results discussed and new experiments designed have impact on areas such as cancer (ABC transporters), vision/ depression/ cardiovascular diseases (G-protein coupled receptors), neurodegenerative diseases, skin diseases, deafness, and developmental abnormalities (connexins) to neurological diseases (ion channels).