CLINICAL RESEARCH SKILLS DEVELOPMENT

临床研究技能发展

• 批准号: 7394654
• 负责人: Augustine M Choi
• 金额: $ 14.85万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-12 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7394654
• 关键词: Address; Basic Science; Bioinformatics; Chronic Obstructive Airway Disease; Clinical; Clinical Investigator; Clinical Medicine; Clinical Research; Clinical Skills; Communication; Critical Care; Daily; Databases; Development; Diagnosis; Diagnostic; Diagnostic tests; Disease Progression; Drug toxicity; Education; Educational Curriculum; Educational process of instructing; Enrollment; Ensure; Environment; Evolution; Faculty; Fostering; Funding; Future; Genes; Genetic; Genetic Polymorphism; Genomics; Growth; Guidelines; Hand; Health; Health Services Research; Healthcare; Human; Human Genome; Hypersensitivity; Internal Medicine; Intervention; K-Series Research Career Programs; Laboratories; Lung; Lung diseases; Measurement; Medicine; Mentors; Modality; Molecular; Nature; Outcome; Outcome Measure; Pathogenesis; Patient Care; Pharmaceutical Preparations; Physicians; Physiological; Postdoctoral Fellow; Reporting; Research; Research Methodology; Research Personnel; Research Training; Resources; Scientist; Stream; Structure; System; Technology; Testing; Therapeutic; Toxic effect; Training; Training Programs; Translating; Translational Research; United States National Institutes of Health; Universities; Vocabulary; Week; Work; base; career; combinatorial; cost; design; disease classification; experience; functional genomics; human disease; interdisciplinary approach; knowledge base; novel diagnostics; programs; response; skills; tool

The successful sequencing of the human genome, and the evolution of human health services research, has produced an era of unprecedented growth in the knowledge base of the molecular and physiological basis of human diseases. The abundance of high throughput genetic and genomic technologies and the rapid spread of information dictated by exponential increase in computing power and communication technology are transforming the practice of clinical medicine and clinical research. The recently developed NIH Roadmap makes clear the importance of clinical research and addresses the ways in which clinical research needs to be transformed to keep pace with laboratory, genetic, and especially genomic research and to ensure that findings are tested and effectively translated into improvements in health and health care. The main objective of this Clinical Research Skills Development Core (CRSDC) is to provide a structured, intensive research experience for physicians, physician-scientists, or scientists trainees to foster the development of skills needed to pursue a successful career in investigative clinical research in the study of chronic obstructive lung disease (COPD). We will utilize a multidisciplinary approach, focusing on the functional genomics of human COPD. CRSDC described here addresses this challenge by providing an integrated training program for junior investigators. In keeping within the guidelines of this Core, we will include trainees at postdoctoral fellow or junior faculty up to their K award training period. The CRSDC has the following specific aims: Specific Aim 1: To offer a core curriculum that integrates clinical research skills with hands-on genomics and bioinformatics training using existing programs at the University of Pittsburgh. Specific Aim 2: To develop a cross-disciplinary mentoring system that will allow junior investigators to develop their research skills and to become independent and productive clinical investigators.

人类基因组测序的成功，以及人类健康服务研究的发展， 产生了一个前所未有的增长时代的分子和生理基础的知识基础， 人类疾病。高通量遗传和基因组技术的丰富和快速的 计算能力和通信技术的指数增长决定了信息的传播 正在改变临床医学和临床研究的实践。最近开发的NIH 路线图明确了临床研究的重要性，并提出了临床研究的方法。 需要进行改造，以跟上实验室，遗传，特别是基因组研究的步伐， 确保对调查结果进行检验，并将其有效地转化为健康和保健方面的改善。的 本临床研究技能发展核心（CRSDC）的主要目标是提供一个结构化的， 医生，医生科学家或科学家实习生的密集研究经验，以促进 发展在研究临床研究中追求成功职业所需的技能， 慢性阻塞性肺疾病（COPD）。我们将采用多学科方法，重点关注 人COPD的功能基因组学。此处描述的CRSDC通过提供 初级调查员综合培训方案。在遵循本核心的指导方针的同时，我们将 包括在博士后研究员或初级学院受训人员，直至他们的K奖培训期。 该委员会有以下具体目标： 具体目标1：提供一个核心课程，将临床研究技能与实践相结合 利用匹兹堡大学现有的项目进行基因组学和生物信息学培训。 具体目标2：建立一个跨学科的指导制度，使初级调查人员能够 发展他们的研究技能，成为独立和富有成效的临床研究者。