CORE--BLOOD AND TISSUE SPECIMEN

描述（由申请人提供）：该中心将作为血液和组织研究的重要资源中心，以完成与脑出血和缺血性梗死的积极介入治疗相关的研究项目。它将为研究患者的血液和组织分析带来与中风发病机制相关的形态解剖学技术的丰富专业知识，并为研究患者的活检和尸检标本的脑组织样本的关键研究者提供途径。该核心将支持项目1，即MR RESCUE试验，其中血管内血栓材料将在治疗性血栓切除术过程中被移除。该核心将帮助研究人员研究血栓形成的生化发病机制及其在脑梗死演变中的可能重要性，并将帮助研究人员将他们的发现与血栓的光镜/超微结构特征联系起来。核心也会

DESCRIPTION (provided by the applicant): This Core will serve as a vital resource center for blood and tissue-based studies integral to the completion of investigational projects, related to aggressive, interventional treatment of cerebral hemorrhage and ischemic infarcts. It will bring to analyses of blood and tissues derived from study patients a wealth of expertise in morphoanatomical techniques pertinent to stroke pathogenesis, and provide access to key investigators of samples of brain tissue derived from biopsy and autopsy specimens of study patients. The core will support Project 1, the MR RESCUE trial, in which intravascular thrombus material will be removed in the course of therapeutic thrombectomy. The core will assist investigators studying the biochemical pathogenesis of thrombus formation, and its possible importance in evolution of cerebral infarcts, and will assist investigators in correlating their findings with light microscopic/ultrastructural features of the thrombi. The core will also provide support to Project 2, the HEME Surgery trial, in which brain tissue originating from 'clot' evacuations carried out in patients with spontaneous intracerebral (parenchymal) hemorrhage will be carefully evaluated for both the likely etiology of hemorrhage and the tissue response to intracerebral blood, and readied for studies of differential gene expression employing qualitative, real-time RT-PCR and cDNA arrays. The Core will store blood samples from appropriate patients for DNA analysis, and provide these to researchers following appropriate review of their investigational goals and projects. The Core will serve as an important 'blood and brain tissue' resource to SPOTRIAS investigators at UCLA, and a larger network of investigators with interests in the treatment of acute ischemic and hemorrhagic stroke.