Portable Liquid-Fueled Catalytic Heater for Infusion Fluids

用于输液的便携式液体燃料催化加热器

• 批准号: 7537979
• 负责人: LINDA A TEMPELMAN
• 金额: $ 14.41万
• 依托单位: GINER, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2009-08-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7537979
• 关键词: Air; Anesthesia procedures; Area; Arts; Blood; Body Temperature; Caring; Cells; Charge; Complex; Computer Simulation; Condition; Construction Materials; Coupling; Developed Countries; Developing Countries; Development; Devices; Disasters; Distant; Economics; Emergency Situation; Emergency treatment; Engineering; Equipment; Erythrocytes; Generations; Goals; Heating; Hemorrhage; Hour; Hurricane; IV Fluid; Infusion procedures; Life; Liquid substance; Mechanics; Medical; Medical Device; Membrane; Methanol; Methods; Military Medicine; Military Personnel; Modeling; Monitor; Numbers; Operative Surgical Procedures; Outcome; Oxygen; Patient Care; Patients; Permeability; Phase; Physicians; Process; Property; Public Health; Range; Rate; Reaction; Research; Research Infrastructure; Services; Shock; Side; Solutions; Structure; Surface; System; Technology; Temperature; Testing; Transmembrane Transport; Trauma; Universities; aqueous; base; catalyst; commercial application; cost; crystalloid; design; energy balance; heat exchanger; improved; innovation; intravenous administration; medical schools; milliliter; natural hypothermia; oxidation; programs; prototype; research study; size; stem; treatment site; vapor

DESCRIPTION (provided by applicant): Portable Liquid-Fueled Catalytic Heater for Infusion Fluids The overall objective of this project is to develop a lightweight, portable, low-cost device powered by liquid fuel for warming intravenous fluids in-the-field distant from medical infrastructure. Excessive hemorrhage, hypothermia and the accompanying shock are among the emergency conditions that often require timely intravenous infusion of large volumes of warmed infusion fluids such as crystalloid or packed red cells. On-site treatment of trauma victims with warmed, intravenous fluids during the critical first hour after the onset of a medical emergency requires effective portable equipment that is not yet available. The portable intravenous fluid warmer would be used in: remote areas, disasters such as hurricanes or terrorist attacks, developing countries, and field military medicine. The major innovation of this project is development of a reusable, portable heater for infusion fluids that uses a non-flammable liquid fuel to provide heating capacity for the full range of trauma treatment in disaster situations. Existing portable technology, powered by batteries, lacks sufficient energy to heat the high volumetric flow rate infusions (up to 500 milliters/minute) needed in trauma treatment. This Phase I project will demonstrate feasibility of a design for a liquid-fueled catalytic heater for warming 60 units of refrigerated infusion fluids (for treating up to 20 patients) using one 500-mL fuel cartridge. The Phase I project will include development of a controlled method for supplying liquid fuel to a catalytic heater, design of the catalytic heater hardware, and integration of the catalytic heater with a medical cartridge-type heat exchanger, culminating in demonstration of a breadboard system for heating refrigerated infusion solutions. A preliminary design for an advanced prototype system will be developed and analyzed to determine the technical and economic feasibility of the device for commercial applications. In Phase II, the advanced design will be implemented and extensively tested to provide a prototype device leading to a commercial product. Commercial Potential: There is a large need for portable, self-powered medical devices for emergency treatment in disaster situations, such as hurricanes or terrorist attacks, and in remote areas. The military also has a great need for emergency equipment for field medical treatment. The proposed device would have high commercial potential since it would have widespread applicability for emergency treatment and would be low-cost and have a long service life. PUBLIC HEALTH RELEVANCE: The overall objective of this project is to develop a lightweight, portable, low-cost intravenous fluid warming device powered by liquid fuel for in-the-field medical care more than one hour distant from medical infrastructure. Excessive hemorrhage, hypothermia and the accompanying shock state are among the emergency conditions that often demand timely intravenous infusion of large volumes of warmed infusion fluids such as crystalloid or packed red cells. This portable, intravenous fluid warmer would significantly improve emergency patient care and outcomes in remote areas, disasters such as hurricanes or terrorist attacks, developing countries, and field military medicine.

描述（由申请人提供）：用于输注流体的便携式液体燃料催化加热器本项目的总体目标是开发一种由液体燃料驱动的轻质、便携式、低成本设备，用于在远离医疗基础设施的现场加热静脉内流体。过度出血、体温过低和伴随的休克属于紧急情况，通常需要及时静脉输注大量温热的输注液，如晶体或浓缩红细胞。在医疗紧急情况发生后的关键第一个小时内，用温热的静脉输液对创伤受害者进行现场治疗，需要有效的便携式设备，但目前还没有。便携式静脉输液加温器将用于：偏远地区，飓风或恐怖袭击等灾害，发展中国家和野战军事医学。该项目的主要创新是开发一种可重复使用的便携式输液加热器，该加热器使用不易燃的液体燃料，为灾害情况下的各种创伤治疗提供加热能力。现有的由电池供电的便携式技术缺乏足够的能量来加热创伤治疗中所需的高体积流速输注（高达500毫升/分钟）。该I期项目将证明液体燃料催化加热器设计的可行性，该加热器使用一个500 mL燃料盒加热60单位的冷冻输液（用于治疗多达20名患者）。第一阶段项目将包括开发一种向催化加热器供应液体燃料的受控方法，设计催化加热器硬件，以及将催化加热器与医用板式热交换器集成，最终演示用于加热冷藏输液的试验板系统。将开发和分析先进原型系统的初步设计，以确定该装置商业应用的技术和经济可行性。在第二阶段，先进的设计将得到实施和广泛的测试，以提供一个原型设备，导致商业产品。商业潜力：对于便携式、自供电的医疗设备存在巨大的需求，用于在诸如飓风或恐怖袭击的灾害情况下以及在偏远地区的紧急治疗。军队对野战医疗应急装备也有很大的需求。拟议的装置将具有很高的商业潜力，因为它将广泛适用于紧急治疗，成本低，使用寿命长。公共卫生关系：该项目的总体目标是开发一种由液体燃料驱动的轻型、便携式、低成本静脉输液加温装置，用于距离医疗基础设施一小时以上的现场医疗护理。过度出血、体温过低和伴随的休克状态是通常需要及时静脉输注大量温热输注流体（例如晶体或浓缩红细胞）的紧急情况。这种便携式静脉输液加温器将显著改善偏远地区、飓风或恐怖袭击等灾害、发展中国家和战地军事医学的急诊病人护理和结果。