Electrochemical Home Monitoring System for Lithium Blood Level

描述(由申请人提供)： 锂的电化学家居监测系统以碳酸锂形式存在的锂是治疗双相情感障碍和其他疾病的重要药物选择。然而，锂的治疗范围很窄，它的使用需要仔细监测患者的锂血液水平，特别是在治疗开始期间。目前的监测技术既不方便又昂贵，需要临床分析实验室。目前还没有商业上可用的家用血锂测量系统。该计划将开发一种先进、快速和方便的家庭系统，可以对接受锂治疗的人的健康产生重大影响，并鼓励在医疗条件允许的情况下充分使用锂治疗。这项工作的创新之处在于开发了一种由高性能微电极与灵敏和选择性的电分析技术相结合的电化学传感器，该传感器可以在以非水为主的电化学环境中测量临床重要范围(每升0.2-3.0毫米分子)的血液样本中的锂浓度。Giner，Inc.将扩大其在锂检测方面的初步数据，并利用其在拟议的电化学技术和电极材料方面的经验。该技术的一个主要优点是，电化学技术可以被封装到仪器中，在家里进行自动化操作，与其他基于实验室的分析技术相比，这使得它们非常便宜和方便。最终产品将具有家用血糖监测仪的易用性，并为临床医生提供患者最佳和经济有效的治疗所需的实时锂测量数据。虽然双相情感障碍有多种药物治疗方法，但在美国570万确诊患者中，约有20%的患者使用锂作为治疗的一部分。建议的产品可供患者在家中使用，也可供临床医生在办公室就诊时使用。 公共卫生相关性： 该SBIR研发计划的总体目标是开发一种供患者使用的基于家庭的血锂监测系统。锂的血液水平非常关键；因此，双相情感障碍患者现在被要求进行频繁的实验室血液测试。以家庭为基础的系统将为患者提供便利，同时改善治疗并降低医疗成本。

DESCRIPTION (provided by applicant): Electrochemical Home Monitoring System for Lithium Blood Level Lithium in the form of lithium carbonate is an important pharmacological treatment option in bipolar disorder and other conditions. However, lithium has a narrow therapeutic treatment range and its use requires careful monitoring of a patient's lithium blood level, particularly during the initiation of treatment. Current monitoring techniques are inconvenient and costly, requiring a clinical analytical laboratory. There is no commercially- available system for home measurement of blood lithium. This program will develop an advanced, rapid, and convenient home system which could make a significant impact in the health of those individuals being treated with lithium and encourage full therapeutic use of lithium when the medical condition merits. The innovation in the proposed work is to develop an electrochemical sensor comprised of a high performance microelectrode combined with a sensitive and selective electroanalytical technique in a predominantly nonaqueous electrochemical environment to measure lithium concentration in the clinically important range (0.2 - 3.0 millimoles per liter) from (aqueous) blood samples. Giner, Inc. will expand on its preliminary data on lithium detection and utilize its experience with the proposed electrochemical techniques and electrode materials. A major advantage of the proposed technology is that electrochemical techniques can be packaged into instruments for automated operation in the home which makes them very inexpensive and convenient compared to other laboratory-based analytical techniques. The final product will have the ease-of-use of a home glucose monitor and provide the clinician with real-time lithium measurements needed for optimal and cost-effective treatment of the patient. While there are multiple pharmacotherapy treatments for bipolar disorder, approximately 20% of the 5.7 million diagnosed patients in the U.S. use lithium as part of their treatment. The proposed product could be used in the home by the patient and also by the clinician during office visits. PUBLIC HEALTH RELEVANCE: The overall goal of this SBIR research and development program is the development of a home-based monitoring system for blood lithium for patient's use. The lithium blood level is very critical; therefore, bipolar disorder patients are now required to have frequent laboratory blood tests. A home-based system would provide convenience for patients while improving treatment and decreasing health care costs.