CART: A NOVEL COCAINE REGULATED NEUROCHEMICAL

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Very substantial progress has been made over the past year. The major finding has been the identification of a CART receptor in AtT20 cells by signaling and binding. This advance will allow screening of potential medications at the receptor and provide tools for cloning the receptor. In addition, we provided evidence that CART knockout mice have a variety of behavioral changes which supports many papers indicating an important role for CART in many physiological processes. We also found that CART has a role in pain and stress which are also worthwhile from the point of view of drug development. In a math modeling study, we showed that the onset of drug dependence fits a model of protein synthesis.