KANSAS U COBRE: GENETIC MODELS OF CONGENITAL VASCULAR MALFORMATIONS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 该项目的工作是了解先天性血管畸形的起源。 这些努力特别关注Klippel Trenaunay综合征的遗传基础，以及基因VG5Q在这种疾病中的作用。 正在开发动物模型以了解该因子的功能，以及开发该疾病的模型。 该项目的期望是在分子水平上了解这种基因产物如何发挥作用以及它如何干扰胎儿血管系统的正常发育。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The work in the project is to develop an understanding of the origins of congenital vascular malformations. These efforts are specifically looking at the genetic basis of Klippel Trenaunay Syndrome, and the role of the gene VG5Q in this disease. Animal models are being developed to understand the functions of this factor, as well as to develop a model of this disease. The expections of this project are to understand, at a molecular level, how this gene product functions and how it interferes with normal development of the fetal vasculature.