Vermont Immunobiology / Infectious Diseases Center

描述（由申请人提供）： 本申请建议在佛蒙特大学（UVM）建立一个生物医学研究卓越中心（COBRE），研究传染性病原体的免疫反应。它将汇集来自6个部门和3个学院的优秀高级指导教师和非常有前途的初级教师。免疫学家主任（拉尔夫·巴德博士），微生物学家联合主任（加里沃德博士），共有7名高级指导教师，以及内部和外部咨询委员会将密切合作，为5名初级教师提供知识基础设施，并启动佛蒙特州免疫生物学/传染病中心（维克）。该提案的具体目标是： 具体目标1;建立研究和知识基础设施，以支持一个大学范围内的中心，用于研究对传染性病原体的免疫反应。 a.建立一个指导计划，以支持初级免疫学/微生物学教师，将包括直接 为每个初级教员分配两名高级教员，提供有关赠款写作、科学伦理和职业咨询的课程。 B.扩展蛋白质组学和微阵列的核心，这将有利于初级和高级指导教师。 C.在免疫学/传染病方面建立一个全校范围的系列研讨会，以及为所有COBRE人员以及内部和外部咨询委员会举办的年度务虚会。 D.建立基础科学家和临床医生之间的沟通机制，促进转化研究的发展。 e.促进免疫学/传染病研究生教育在基础和临床水平更强的培训环境。 F.招募3名免疫学，传染病和微生物发病机制的新教师。 具体目标2：支持一批将成为维克国际中心未来领导者的初级教员的研究发展。 a. Jonathan Boyson博士CDld及其配体激活iNKT细胞的分子决定因素 B.贝丝·D柯克帕特里克，医学博士T细胞与微小隐孢子虫天然免疫 C. Christopher休士顿，医学博士溶组织内阿米巴吞噬作用与炎症。 D. Mariana Matrajt博士宿主细胞对弓形虫信号转导的颠覆 e. M. Gustavo Pedraza博士炭疽毒素对p38 MAP激酶活性的影响

DESCRIPTION (provided by applicant): This application proposes the establishment of a Center of Biomedical Research Excellence (COBRE) in Immune Responses to Infectious Pathogens at The University of Vermont (UVM). It will bring together talented senior mentoring faculty and highly promising junior faculty from 6 departments and 3 colleges. An immunologist Director (Dr. Ralph Budd), a microbiologist Co-Director (Dr. Gary Ward), a total of 7 senior mentoring faculty, and Internal and External Advisory Committees will work closely together to provide an intellectual infrastructure for 5 junior faculty, and initiate the Vermont Immunobiology/Infectious Diseases Center (VIC). The specific aims of the proposal are: Specific Aim 1; Establish the research and intellectual infrastructure to support a University-wide center for the study of the immune responses to infectious pathogens. a. Establish a mentoring program to support junior Immunology/Microbiology faculty that will include direct assignment of two senior faculty for each junior faculty, offer courses on grant writing, ethics in science, and career counseling. b. Expand cores in Proteomics and Microarray that will benefit both the junior and senior mentoring faculty. c. Establish a University-wide seminar series in Immunology/Infectious Diseases, as well as an annual retreat for all COBRE personnel, and Internal and External Advisory Committees. d. Establish a mechanism of communication between basic scientists and clinicians that facilitates development of translational research. e. Promote a stronger training environment for Graduate Education in Immunology/Infectious Diseases, both at the basic and clinical levels. f. Recruitment of 3 new faculty in Immunology, Infectious Diseases, and microbial pathogenesis. Specifjc Aim 2; Support the research development of a group of junior faculty who will be the future leaders of the VIC. a. Jonathan Boyson, Ph.D. Molecular Determinants of iNKT cell Activation by CDld and Its Ligands. b. Beth D. Kirkpatrick, M.D. T Cells and Innate Immunity to Cryptosporidium parvum c. Christopher Huston, M.D. Entamoeba histolytica phagocytosis and inflammation. d. Mariana Matrajt, Ph.D. Subversion of Host Cell Signaling to Toxoplasma gondii e. M. Gustavo Pedraza, Ph.D. The effect of anthrax toxin on p38 MAP kinase activation