Vermont Immunobiology / Infectious Diseases Center

佛蒙特州免疫生物学/传染病中心

• 批准号: 7647047
• 负责人: Ralph C Budd
• 金额: $ 216.67万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7647047
• 关键词: Vermont; Immunobiology; Infectious; Diseases; Center

DESCRIPTION (provided by applicant): This application proposes the establishment of a Center of Biomedical Research Excellence (COBRE) in Immune Responses to Infectious Pathogens at The University of Vermont (UVM). It will bring together talented senior mentoring faculty and highly promising junior faculty from 6 departments and 3 colleges. An immunologist Director (Dr. Ralph Budd), a microbiologist Co-Director (Dr. Gary Ward), a total of 7 senior mentoring faculty, and Internal and External Advisory Committees will work closely together to provide an intellectual infrastructure for 5 junior faculty, and initiate the Vermont Immunobiology/Infectious Diseases Center (VIC). The specific aims of the proposal are: Specific Aim 1; Establish the research and intellectual infrastructure to support a University-wide center for the study of the immune responses to infectious pathogens. a. Establish a mentoring program to support junior Immunology/Microbiology faculty that will include direct assignment of two senior faculty for each junior faculty, offer courses on grant writing, ethics in science, and career counseling. b. Expand cores in Proteomics and Microarray that will benefit both the junior and senior mentoring faculty. c. Establish a University-wide seminar series in Immunology/Infectious Diseases, as well as an annual retreat for all COBRE personnel, and Internal and External Advisory Committees. d. Establish a mechanism of communication between basic scientists and clinicians that facilitates development of translational research. e. Promote a stronger training environment for Graduate Education in Immunology/Infectious Diseases, both at the basic and clinical levels. f. Recruitment of 3 new faculty in Immunology, Infectious Diseases, and microbial pathogenesis. Specifjc Aim 2; Support the research development of a group of junior faculty who will be the future leaders of the VIC. a. Jonathan Boyson, Ph.D. Molecular Determinants of iNKT cell Activation by CDld and Its Ligands. b. Beth D. Kirkpatrick, M.D. T Cells and Innate Immunity to Cryptosporidium parvum c. Christopher Huston, M.D. Entamoeba histolytica phagocytosis and inflammation. d. Mariana Matrajt, Ph.D. Subversion of Host Cell Signaling to Toxoplasma gondii e. M. Gustavo Pedraza, Ph.D. The effect of anthrax toxin on p38 MAP kinase activation

描述（由申请人提供）： 该申请提议在佛蒙特大学 (UVM) 建立传染性病原体免疫反应生物医学卓越研究中心 (COBRE)。它将汇集来自6个系和3个学院的才华横溢的高级导师和极具潜力的初级教师。免疫学家主任（Ralph Budd 博士）、微生物学家联合主任（Gary Ward 博士）、总共 7 名高级导师以及内部和外部咨询委员会将密切合作，为 5 名初级教师提供知识基础设施，并启动佛蒙特州免疫生物学/传染病中心（VIC）。该提案的具体目标是： 具体目标1；建立研究和知识基础设施，以支持大学范围内的传染性病原体免疫反应研究中心。 一个。建立一个指导计划来支持初级免疫学/微生物学教师，其中包括直接 为每个初级教师分配两名高级教师，提供有关资助写作、科学伦理和职业咨询的课程。 b.扩展蛋白质组学和微阵列的核心，这将使初级和高级指导教师受益。 c.建立全大学免疫学/传染病系列研讨会，并为所有 COBRE 人员以及内部和外部咨询委员会举办年度静修会。 d.建立基础科学家和临床医生之间的沟通机制，促进转化研究的发展。 e.在基础和临床层面促进免疫学/传染病研究生教育更强大的培训环境。 f.招聘 3 名免疫学、传染病和微生物发病机制新教师。 具体目标 2；支持一批初级教师的研究发展，他们将成为 VIC 未来的领导者。 一个。乔纳森·博伊森博士CD1d及其配体激活iNKT细胞的分子决定因素。 b. Beth D. Kirkpatrick，医学博士 T 细胞和对小隐孢子虫的先天免疫 c. Christopher Huston，医学博士溶组织内阿米巴吞噬作用和炎症。 d.玛丽安娜·马特拉吉特博士弓形虫宿主细胞信号传导的颠覆 e. M.古斯塔沃·佩德拉萨博士炭疽毒素对 p38 MAP 激酶激活的影响