OPTICAL DOPPLER TOMOGRAPHY(ODT) BURN DEPTH DETERMINATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 为了优化清创的准确性，烧伤外科医生必须在皮肤和烧伤结痂的不同水平上确定可存活的皮肤循环。从焦痂下面的组织或烧伤皮肤的停滞区发出的“存活的ODT信号”可能表明，外科医生在切除强有力的灌流组织之前已经到达了停滞区。如果这种外科手术的精确度或精确度是可能的，那么只有无血管坏死的皮肤将被切除，从而保护了潜在的组织，并减少了输血、麻醉和植皮的需要。根据ODT提供的信息，烧伤外科医生可以在手术前决定烧伤伤员的两种可能的治疗计划之一：(A)在烧伤创面演变和伤口愈合开始时集中支持患者；或(B)立即进行烧伤清创和植皮。术中，ODT为烧伤清创术的最佳深度提供指导，直至最终闭合。术后，ODT可用于监测生理上有意义的愈合事件，包括新生血管。快速、准确地对大面积和不同深度的存活组织进行成像和区分将对主治烧伤外科医生大有裨益。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To optimize the accuracy of debridement, the burn surgeon must determine the viable cutaneous circulation at different levels in the skin and burn eschar. A "viable ODT signal" from the tissue underlying the eschar, or from the zone of stasis of burned skin, could indicate that the surgeon has reached the zone of stasis before excising vigorously perfused tissue. If this surgical precision or accuracy were possible, only the avascular necrotic skin would be removed, thereby conserving underlying tissue and decreasing the need for blood transfusions, anesthesia, and skin grafting. From information provided by ODT, preoperatively, the burn surgeon can decide on one of two possible treatment plans for casualties with burn injuries (a) concentrate on supporting the patient while the burn wound evolves and wound healing begins; or (b) immediate burn debridement with skin grafting. Intraoperatively, ODT provides guidance regarding the optimal depth for burn debridemen t p rior to definitive closure. Postoperatively, ODT can be used to monitor physiologically significant healing events including neovascularization. The potential to rapidly and accurately image and distinguish viable from nonviable tissue over large areas and at different depths would be of enormous benefit to the attending burn surgeon.