INTERACTIONS BETWEEN PROTEINS OF THE MEIOTIC SPINDLE POLE BODY
减数分裂纺锤体蛋白质之间的相互作用
基本信息
- 批准号:7723749
- 负责人:
- 金额:$ 1.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-01 至 2009-08-31
- 项目状态:已结题
- 来源:
- 关键词:Computer Retrieval of Information on Scientific Projects DatabaseElectron MicroscopyFundingGrantGrowthInstitutionMeiosisMembraneMethodologyMicrotubulesProteinsReproduction sporesResearchResearch PersonnelResourcesSiteSourceStructureUnited States National Institutes of Healthbasespindle pole bodyyeast two hybrid system
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
During meiosis, the outer plaque of the spindle pole body (SPB) is reorganized.The structure is converted from a site of microtubule growth to one of membrane formation and anchorage. These membranes, termed prospore membranes, are essential for the formation of spores. Electron microscopy analysis reveals a very highly organized structure for the meiotic outer plaque, and two-hybrid analyses have identified many interactions between these outer plaque proteins. However, precisely how these proteins are organized with respect to each other within the outer plaque is not known. The arrangement of these proteins within the outer plaque will be explored by FRET-based methodology.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
在减数分裂过程中,纺锤体极体(SPB)的外层斑块发生重组,其结构由微管生长的场所转变为膜形成和锚定的场所。这些膜称为原孢子膜,是孢子形成所必需的。电子显微镜分析揭示了一个非常有组织的结构减数分裂外斑,和双杂交分析已经确定了这些外斑蛋白之间的许多相互作用。然而,这些蛋白质在外斑块内如何相互组织尚不清楚。这些蛋白质的安排内的外部斑块将探索FRET为基础的方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Aaron M Neiman其他文献
Aaron M Neiman的其他文献
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{{ truncateString('Aaron M Neiman', 18)}}的其他基金
INTERACTIONS BETWEEN PROTEINS OF THE MEIOTIC SPINDLE POLE BODY
减数分裂纺锤体蛋白质之间的相互作用
- 批准号:
8365796 - 财政年份:2011
- 资助金额:
$ 1.95万 - 项目类别:
Chromatin and the Control of Late Meiotic Gene Expression
染色质和减数分裂晚期基因表达的控制
- 批准号:
7917077 - 财政年份:2010
- 资助金额:
$ 1.95万 - 项目类别:
TRAINING IN LIVE CELL FLUORESCENCE MICROSCOPY AND FRET ANALYSIS
活细胞荧光显微镜和微丝分析培训
- 批准号:
7957817 - 财政年份:2009
- 资助金额:
$ 1.95万 - 项目类别:
Developmental Regulation of the Secretory Pathway in Yeast
酵母分泌途径的发育调控
- 批准号:
7929176 - 财政年份:2009
- 资助金额:
$ 1.95万 - 项目类别:
TRAINING IN LIVE CELL FLUORESCENCE MICROSCOPY AND FRET ANALYSIS
活细胞荧光显微镜和微丝分析培训
- 批准号:
7723719 - 财政年份:2008
- 资助金额:
$ 1.95万 - 项目类别:
INTERACTIONS BETWEEN PROTEINS OF THE MEIOTIC SPINDLE POLE BODY
减数分裂纺锤体蛋白质之间的相互作用
- 批准号:
7420716 - 财政年份:2006
- 资助金额:
$ 1.95万 - 项目类别:
INTERACTIONS BETWEEN PROTEINS OF THE MEIOTIC SPINDLE POLE BODY
减数分裂纺锤体蛋白质之间的相互作用
- 批准号:
7182437 - 财政年份:2005
- 资助金额:
$ 1.95万 - 项目类别:
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