Nutrition and Superfund Chemical Toxicity

营养和超级基金化学毒性

• 批准号: 7389158
• 负责人: BERNHARD HENNIG
• 金额: $ 194.17万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-07 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7389158
• 关键词: Nutrition; Superfund; Chemical; Toxicity

DESCRIPTION (provided by applicant) The University of Kentucky is unique among land grant universities in that all colleges, including Medicine and Agriculture, are located on the same campus. This constellation of programs has enabled the UK-SBRP to develop uniquely productive collaborations across diverse disciplines. Such an environment will allow to study the overall theme of the SBRP research, which focuses on the toxicology of Superfund chemicals and how health effects of exposure can be modulated by both intrinsic and extrinsic factors, namely genetics and nutrition, respectively. Given the abundance of Superfund chemicals and widespread distribution in the ecosystem, it is unlikely that remediation alone will be sufficient to address their health risks. Nutritional intervention thus becomes a sensible way to address health problems associated with environmental pollutants. In the competing renewal, the investigators recognize this dual need for sensing/remediation and biomedical intervention through nutrition by proposing five integrated projects. The investigators will concentrate on chlorinated organics (e.g., polychlorinated biphenyls) prevalent in most Superfund sites, including those found in Kentucky. Preliminary findings by this group suggest that nutrition and dietary habits can markedly influence mechanisms of toxicity of the above-mentioned Superfund chemicals. Thus, a major objective of our SBRP is to explore the paradigm that nutrition can modify Superfund chemical toxicity. All biomedical projects will focus on chronic diseases associated with vascular dysfunction, such as cardiovascular disease, cancer metastasis, and obesity-related abdominal aortic aneurysms, and will utilize a similar dietary fat regimen to study nutrient/toxicant interactions. There will be significant cross-talk with non-biomedical projects, which will explore novel techniques for both remediation (detoxification) and biosensors associated with detection of PCBs and other chlorinated organics. Results from interdisciplinary research will be utilized for information/education, technology transfer, training, policy and translational purposes as part of the objectives of the Research Translation, Community Outreach, and Training Cores. Nutrition may be the most sensible means to develop primary prevention strategies of diseases associated with many environmental toxic insults. Thus, research proposed by the investigators may lead to novel dietary recommendations at the national level for populations at risk, thus improving the health of people residing near Superfund sites. ADMINISTRATIVE CORE Description (provided by applicant) The Administrative Core (Core A) will oversee the entire Superfund Basic Research Program through a management mechanism that allows efficient and accountable oversight and maximum interdisciplinary and multidisciplinary interactions among all participants. The Administrative Core will be responsible for the coordination, planning, assessment, project accounting, and administrative support to the research personnel of the University of Kentucky SBRP. A major objective of the Administrative Core is to facilitate the execution of an interdisciplinary research theme through administrative support and fiscal accountability. The Administrative Core will work especially closely with the Research Translation Core (Core C) to optimize communication with NIEHS, EPA, and state and local constituents; communication is also facilitated by an active website that is managed by Core C with input from the Administrative Core. Research efforts will be coordinated through biweekly meetings of faculty, students and research staff, as well as seminars, where new findings and planned activities and ideas will be discussed. It will also be critical to discuss research findings for informative/educational activities, technology transfer, training, policy and translational purposes as part of the objectives of the Research Translation, Community Outreach, and Training Cores. The Administrative Core will implement feedback and cross-talk between all project and core activities to allow for maximum integration. For example, optimal detection and remediation of Superfund pollutants must be linked to risk assessment and biomedical aspects of degradation products. Accountability of the University of Kentucky SBRP activities, including the quality of science and administration, will be achieved through regular consultations with both the External and Internal Advisory Boards. Research quality assessment and statistical consultation will be managed through the Research Support Core. General fiscal responsibilities or project accounting will be coordinated through the Administrative Office in conjunction with the University of Kentucky Research Foundation. The Program Coordinator together with the Program Director will serve as a regular contact among all SBRP activities, including research projects and cores, and will coordinate all reports required by the sponsoring agencies.

描述（由申请人提供） 肯塔基州大学是唯一的土地赠款大学，因为所有学院，包括医学和农业，都位于同一个校园。这一系列计划使UK-SBRP能够在不同学科之间开展独特的富有成效的合作。这样的环境将允许研究SBRP研究的总体主题，重点是超级基金化学品的毒理学以及如何通过内在和外在因素（即遗传和营养）调节暴露的健康影响。鉴于超级基金化学品的丰富性和在生态系统中的广泛分布，单靠补救措施不太可能足以解决其健康风险。因此，营养干预成为解决与环境污染物有关的健康问题的一种明智的方式。在竞争性的更新中，研究人员通过提出五个综合项目，认识到这种通过营养进行传感/修复和生物医学干预的双重需求。调查人员将集中研究氯化有机物（例如，多氯联苯），包括在肯塔基州发现的那些。该小组的初步研究结果表明，营养和饮食习惯可显著影响上述超级基金化学品的毒性机制。因此，我们SBRP的一个主要目标是探索营养可以改变超级基金化学毒性的范例。所有的生物医学项目将集中在与血管功能障碍相关的慢性疾病，如心血管疾病，癌症转移和肥胖相关的腹主动脉瘤，并将利用类似的饮食脂肪方案来研究营养/有毒物质的相互作用。将与非生物医学项目进行重大的交叉讨论，这些项目将探索与检测多氯联苯和其他氯化有机物有关的补救（解毒）和生物传感器的新技术。跨学科研究的成果将用于信息/教育、技术转让、培训、政策和翻译目的，作为研究翻译、社区外展和培训核心目标的一部分。营养可能是制定与许多环境毒性损伤相关的疾病的初级预防策略的最明智的手段。因此，研究人员提出的研究可能会在国家一级为高危人群提供新的饮食建议，从而改善居住在超级基金地点附近的人们的健康。 行政核心 说明（申请人提供） 行政核心（核心A）将通过一个管理机制监督整个超级基金基础研究计划，该机制允许有效和负责任的监督，并在所有参与者之间进行最大限度的跨学科和多学科互动。行政核心将负责协调，规划，评估，项目会计和行政支持的肯塔基州SBRP大学的研究人员。行政核心的一个主要目标是通过行政支持和财政问责制促进跨学科研究主题的执行。行政核心将与研究翻译核心（核心C）密切合作，以优化与NIEHS，EPA以及州和地方选民的沟通;沟通也由核心C管理的活动网站提供便利。研究工作将通过教师，学生和研究人员的双周会议以及研讨会进行协调，讨论新的发现和计划的活动和想法。讨论信息/教育活动，技术转让，培训，政策和翻译目的的研究结果也将是至关重要的，作为研究翻译，社区推广和培训核心目标的一部分。行政核心将在所有项目和核心活动之间进行反馈和交流，以实现最大程度的整合。例如，对超级基金污染物的最佳检测和补救必须与降解产品的风险评估和生物医学方面联系起来。肯塔基州SBRP活动，包括科学和管理质量的大学的问责制，将通过与外部和内部咨询委员会定期磋商实现。研究质量评估和统计咨询将通过研究支助核心进行管理。一般财务责任或项目会计将通过行政办公室与肯塔基州大学研究基金会协调。项目协调员和项目主任将作为SBRP所有活动的定期联系人，包括研究项目和核心，并将协调赞助机构要求的所有报告。