QUANTIFYING SODIUM IN THE LUMBAR SPINE IN VIVO

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 椎间盘退行性疾病（DDD）是椎骨之间的椎间盘逐渐恶化， 可能是导致成年人腰痛的原因之一。早期DDD的特征是基质丢失 椎间盘髓核（NP）区域中的诸如蛋白聚糖（PG）的成分 disc. 软骨组织中的钠含量与蛋白多糖含量相关， 组织变性的天然生物标志物，钠MRI可作为成像生物标志物 对于DDD。 在这项研究中，我们证明了量化早期退化的潜力， 通过定量离体椎间盘标本以及人类受试者中NP中的钠， 体内通过MRI。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Degenerative Disc Disease (DDD) is a gradual deterioration of the disc between the vertebrae and may be a cause of lower back pain in adults. Early DDD is characterized by a loss of matrix constituents such as proteoglycans (PG) in the nucleus pulposus (NP) region of the intervertebral disc. Sodium content in cartilage tissue correlates with proteoglycan content and can provide a natural biomarker for tissue degeneration and Sodium MRI may serve as an imaging biomarker for DDD. In this study, we demonstrate the potential for quantifying early degeneration in the disc by quantifying sodium in the NP in ex vivo disc specimens as well as in human subjects in vivo via MRI.