MRI EVALUATION OF A GUINEA PIG MODEL OF ARTHRITIS

豚鼠关节炎模型的 MRI 评估

• 批准号: 8169035
• 负责人: Nicola FENTY
• 金额: $ 1.73万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169035
• 关键词: Animal Model; Arthritis; Biochemical; Cartilage; Cavia; Computer Retrieval of Information on Scientific Projects Database; Degenerative polyarthritis; Diagnostic; Evaluation; Extracellular Matrix; Funding; Future; Grant; Imaging Techniques; Institution; Joints; Magnetic Resonance Imaging; Measures; Modeling; Proteoglycan; Relaxation; Research; Research Personnel; Resources; Source; Time; United States National Institutes of Health; Water; articular cartilage; macromolecule

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Conventional T1 and T2 imaging techniques are useful for observing late structural morphological changes to the cartilage within the femoral-tibial joint but are insensitive to early biochemical changes. T1¿ MRI has shown promise as a diagnostic measure of early osteoarthritis. The T1¿ relaxation time constant is sensitivity to the interaction between bulk water molecules and extracellular matrix macromolecules such as the proteoglycans in articular cartilage. In this study, we evaluate the efficacy of T1¿ MRI to characterize osteoarthritis changes in an animal model (Dunkin-Hartley guinea pig) of spontaneous osteoarthritis formation. Future studies may allow T1¿ MRI to evaluate efficacy of potential therapies for OA.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 传统的T1和T2成像技术对于观察晚期结构形态很有用 股骨-胫骨关节内软骨的变化，但对早期生化不敏感 变化T1 <$MRI已显示出作为早期骨关节炎诊断措施的前景。T1 ² 弛豫时间常数对大量水分子之间的相互作用敏感， 细胞外基质大分子如关节软骨中的蛋白多糖。在本研究中， 我们在动物模型中评估了T1 <$MRI表征骨关节炎变化的有效性 （Dunkin-Hartley豚鼠）自发性骨关节炎形成。未来的研究可能会允许T1？ MRI评价OA潜在治疗的有效性。