MRI EVALUATION OF A GUINEA PIG MODEL OF ARTHRITIS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 常规的T1和T2成像技术对于观察晚期结构形态是有用的 股骨-胫骨关节内软骨的变化，但对早期生化反应不敏感 改变。T1？MRI已显示出作为早期骨关节炎的一种诊断手段的前景。T1？ 弛豫时间常数对主体水分子与水分子间相互作用的敏感性 细胞外基质大分子，如关节软骨中的蛋白多糖。在这项研究中， 我们评估了T1？MRI在动物模型中表征骨关节炎变化的有效性 (Dunkin-Hartley豚鼠)自发性骨关节炎形成。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Conventional T1 and T2 imaging techniques are useful for observing late structural morphological changes to the cartilage within the femoral-tibial joint but are insensitive to early biochemical changes. T1¿ MRI has shown promise as a diagnostic measure of early osteoarthritis. The T1¿ relaxation time constant is sensitivity to the interaction between bulk water molecules and extracellular matrix macromolecules such as the proteoglycans in articular cartilage. In this study, we evaluate the efficacy of T1¿ MRI to characterize osteoarthritis changes in an animal model (Dunkin-Hartley guinea pig) of spontaneous osteoarthritis formation.