LONGITUDINAL T1? MRI OF SHEEP FOLLOWING SURGICALLY INDUCED MENISCAL TEAR

纵向T1？

• 批准号: 8169065
• 负责人: Nicola FENTY
• 金额: $ 0.87万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169065
• 关键词: Biochemical; Biomechanics; Cartilage; Computer Retrieval of Information on Scientific Projects Database; Degenerative polyarthritis; Development; Diagnostic; Extracellular Matrix; Female; Funding; Grant; Imaging Techniques; Incidence; Individual; Injury; Institution; Joints; Life; Magnetic Resonance Imaging; Measures; Proteoglycan; Relaxation; Research; Research Personnel; Resources; Sheep; Source; Staging; Stifle joint; Stress; Teenagers; Time; United States National Institutes of Health; Water; articular cartilage; macromolecule

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Conventional T1 and T2 imaging techniques are useful for observing late structural morphological changes to the cartilage within the femoral-tibial joint but are insensitive to early biochemical changes. T1¿ MRI has shown promise as a diagnostic measure of early osteoarthritis. The T1¿ relaxation time constant is sensitivity to the interaction between bulk water molecules and extracellular matrix macromolecules such as the proteoglycans in articular cartilage. Meniscal tears are becoming exceedingly common in the modern active teenager, especially younger females. It has been shown that teenagers who have had meniscal tears develop OA at a higher incidence rate than individuals without these injuries in later stages of life. In this study, we evaluate the biochemical changes of stifle cartilage from surgically induced meniscal tears in sheep. It is predicted that these meniscal tears alter the biomechanical loading conditions of the joint and induce stresses believed to cause OA. We will follow the progression of OA within the joint and begin to develop an applicable treatment to mitigate OA development.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 传统的 T1 和 T2 成像技术可用于观察晚期结构形态 股骨-胫骨关节内的软骨发生变化，但对早期生化不敏感 变化。 T1 MRI 已显示出作为早期骨关节炎的诊断方法的前景。 T1?? 弛豫时间常数是对大量水分子和水分子之间相互作用的敏感性 细胞外基质大分子，例如关节软骨中的蛋白聚糖。半月板 在现代活跃的青少年中，尤其是年轻女性中，流泪变得非常普遍。 研究表明，患有半月板撕裂的青少年患骨关节炎的几率更高 与在生命后期没有受到这些伤害的人相比，发生率更高。 在这项研究中，我们评估了 手术引起的绵羊半月板撕裂引起的膝关节软骨的生化变化。 据预测 这些半月板撕裂改变了关节的生物力学负荷条件并引起应力 据信会导致 OA。 我们将跟踪关节内 OA 的进展并开始开发 适用的治疗方法可减轻 OA 的发展。