T1? IMAGING OF ARTICULAR CARTILAGE AFTER IMPLANTATION OF TIBIAL FRACTURE PLATE
T1?
基本信息
- 批准号:8362017
- 负责人:
- 金额:$ 0.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-06-01 至 2012-05-31
- 项目状态:已结题
- 来源:
- 关键词:AffectBiochemicalBlood VesselsCartilageCartilage MatrixComplexFinancial compensationFractureFundingGrantImageImageryImplantInjuryJointsLigamentsMagnetic ResonanceMagnetic Resonance ImagingMechanicsMethodsModalityNational Center for Research ResourcesOperative Surgical ProceduresPhysiologic pulsePrincipal InvestigatorPropertyProteoglycanProtocols documentationResearchResearch InfrastructureResourcesSiteSourceSurfaceSurgical ManagementTibial FracturesTimeTraumaUnited States National Institutes of Healtharticular cartilagebonecostimplantationoptical imagingosteochondral tissuerepairedsample fixationsoft tissuetibia
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Tibial plateau fractures are a complex group of injuries resulting in damage to bone, cartilage and ligaments that can be challenging to repair. The surgical management is complicated by poor visualization of the often comminuted articular surface, the precarious soft tissue envelope, and the limited surgical exposure available to approach the site of injury. Injuries of articular cartilage alone and osteochondral fractures can be visualized with MRI, which is the only modality for detailed non-invasive assessment of articular cartilage. However, with the insertion of metallic fixation plates, the ability to visualize soft tissue within the affected joint is severely diminished. Several MR methods to compensate for B0 distortions have been discussed but are time intensive and require specialized pulse sequences. T1¿ imaging has been shown to have high sensitivity to quantify proteoglycan content within articular cartilage. With traumatic tibial plateau fractures, the integrity of the cartilage may become compromised due to several factors such as vascular damage via fractures to the subchondral bone, abnormal loading conditions, and mechanical blunt force trauma to the cartilage matrix. Therefore, the aim of this study is to develop a T1¿ MRI protocol with B0 distortion compensation to accurately quantify biochemical properties of the articular cartilage post-fixation of the tibia via metallic implant.
这个子项目是利用这些资源的众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Nicola FENTY其他文献
Nicola FENTY的其他文献
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{{ truncateString('Nicola FENTY', 18)}}的其他基金
LONGITUDINAL T1? MRI OF ADULTS WITH CHONDROMALACIA FOLLOWING ARTHROSCOPY
纵向T1?
- 批准号:
8361975 - 财政年份:2011
- 资助金额:
$ 0.77万 - 项目类别:
T1? & UTE MRI OF SHEEP STIFLES FOLLOWING SURGICALLY INDUCED MENISCAL TEAR
T1?
- 批准号:
8362016 - 财政年份:2011
- 资助金额:
$ 0.77万 - 项目类别:
T1P MRI OF ARTICULAR CARTILAGE FOLLOWING VISCOSUPPLEMENTATION
粘性补充后关节软骨的 T1P MRI
- 批准号:
8362020 - 财政年份:2011
- 资助金额:
$ 0.77万 - 项目类别:
MRI EVALUATION OF A GUINEA PIG MODEL OF ARTHRITIS
豚鼠关节炎模型的 MRI 评估
- 批准号:
8361952 - 财政年份:2011
- 资助金额:
$ 0.77万 - 项目类别:
CEST MRI EVALUATION OF A GUINEA PIG MODEL OF ARTHRITIS
CEST MRI 评估豚鼠关节炎模型
- 批准号:
8362019 - 财政年份:2011
- 资助金额:
$ 0.77万 - 项目类别:
LONGITUDINAL T1? MRI OF ADULTS WITH CHONDROMALACIA FOLLOWING ARTHROSCOPY
纵向T1?
- 批准号:
8169064 - 财政年份:2010
- 资助金额:
$ 0.77万 - 项目类别:
LONGITUDINAL T1? MRI OF SHEEP FOLLOWING SURGICALLY INDUCED MENISCAL TEAR
纵向T1?
- 批准号:
8169065 - 财政年份:2010
- 资助金额:
$ 0.77万 - 项目类别:
REPEATABILITY OF A NOVEL 3D PULSE SEQUENCE FOR MAPPING T1P IN IVD
用于在 IVD 中绘制 T1P 的新型 3D 脉冲序列的可重复性
- 批准号:
8169036 - 财政年份:2010
- 资助金额:
$ 0.77万 - 项目类别:
MRI EVALUATION OF A GUINEA PIG MODEL OF ARTHRITIS
豚鼠关节炎模型的 MRI 评估
- 批准号:
8169035 - 财政年份:2010
- 资助金额:
$ 0.77万 - 项目类别:
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