T1? IMAGING OF ARTICULAR CARTILAGE AFTER IMPLANTATION OF TIBIAL FRACTURE PLATE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 胫骨平台骨折是一组复杂的损伤，导致骨、软骨和韧带受损，修复起来可能具有挑战性。由于关节表面经常粉碎，软组织包膜不稳定，以及可用于接近损伤部位的手术暴露有限，手术处理变得复杂。MRI可以显示单独的关节软骨损伤和骨软骨骨折，是对关节软骨进行详细非侵入性评估的唯一手段。然而，随着金属固定板的插入，显示受影响关节内软组织的能力严重减弱。已经讨论了几种补偿B0失真的MR方法，但这些方法都是时间密集型的，并且需要专门的脉冲序列。T1成像对于定量关节软骨中的蛋白多糖含量具有很高的灵敏度。对于创伤性胫骨平台骨折，软骨的完整性可能会因为几个因素而受到损害，例如软骨下骨骨折造成的血管损伤，异常的负荷条件，以及对软骨基质的机械钝性创伤。因此，本研究的目的是开发一种具有B0失真补偿的T1？MRI方案，以准确地量化经金属植入的胫骨固定后关节软骨的生化特性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Tibial plateau fractures are a complex group of injuries resulting in damage to bone, cartilage and ligaments that can be challenging to repair. The surgical management is complicated by poor visualization of the often comminuted articular surface, the precarious soft tissue envelope, and the limited surgical exposure available to approach the site of injury. Injuries of articular cartilage alone and osteochondral fractures can be visualized with MRI, which is the only modality for detailed non-invasive assessment of articular cartilage. However, with the insertion of metallic fixation plates, the ability to visualize soft tissue within the affected joint is severely diminished. Several MR methods to compensate for B0 distortions have been discussed but are time intensive and require specialized pulse sequences. T1¿ imaging has been shown to have high sensitivity to quantify proteoglycan content within articular cartilage. With traumatic tibial plateau fractures, the integrity of the cartilage may become compromised due to several factors such as vascular damage via fractures to the subchondral bone, abnormal loading conditions, and mechanical blunt force trauma to the cartilage matrix. Therefore, the aim of this study is to develop a T1¿ MRI protocol with B0 distortion compensation to accurately quantify biochemical properties of the articular cartilage post-fixation of the tibia via metallic implant.