T1? MRI OF THE GLENOHUMERAL JOINT CARTILAGE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 肩周炎是一种致残性疾病，可能严重影响生活质量以及娱乐和日常生活活动。原发性肩关节骨关节炎主要发生在老年人；然而，最近有一批年轻患者被描述为肩关节镜检查后的终末期肩周炎。对于肩部损伤，无论是急性创伤事件还是反复应激，软骨的完整性可能会由于几个因素而受到损害，如异常负荷条件和反复应激。关节软骨的损伤可以用MRI显示出来，这是对关节间隙进行详细的非侵入性评估的唯一方法。关节软骨的骨关节炎改变，如蛋白多糖分子的丢失和破坏，已经用T1？MRI进行了高灵敏度的量化。因此，本研究的目的是建立一种T1？MRI方法来准确定量关节软骨的生化特性，以监测体内软骨退变的发展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Glenohumeral arthritis is a disabling condition and may severely affect quality of life and activities of recreation and daily living. Primary glenohumeral osteoarthritis predominantly occurs in older individuals; however, a younger cohort of patients has been recently described with end stage glenohumeral arthritis after shoulder arthroscopy. With shoulder injuries, either acute traumatic event or repetitive stress, the integrity of the cartilage may become compromised due to several factors such as abnormal loading conditions and repeated stresses. Injuries to the glenohumeral articular cartilage can be visualized with MRI, which is the only modality for detailed non-invasive assessment of this joint space. Osteoarthritic changes to articular cartilage such as loss and breakdown of proteoglycan molecules has been quantified with high sensitivity with T1¿ MRI . Therefore, the aim of this study is to develop a T1¿ MRI protocol to accurately quantify biochemical properties of the glenohumeral articular cartilage to monitor the development of cartilage degeneration in vivo.