T1? MRI OF THE GLENOHUMERAL JOINT CARTILAGE

T1？

• 批准号: 8362018
• 负责人: Nicola FENTY
• 金额: $ 0.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362018
• 关键词: Acute; Affect; Arthritis; Arthroscopy; Biochemical; Cartilage; Degenerative polyarthritis; Event; Funding; Grant; Individual; Injury; Joints; Life; Magnetic Resonance; Magnetic Resonance Imaging; Modality; Monitor; National Center for Research Resources; Osteoarthrosis Deformans; Patients; Principal Investigator; Property; Proteoglycan; Protocols documentation; Quality of life; Recreation; Research; Research Infrastructure; Resources; Shoulder; Source; Staging; Stress; United States National Institutes of Health; articular cartilage; cartilage development; cohort; cost; in vivo; optical imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Glenohumeral arthritis is a disabling condition and may severely affect quality of life and activities of recreation and daily living. Primary glenohumeral osteoarthritis predominantly occurs in older individuals; however, a younger cohort of patients has been recently described with end stage glenohumeral arthritis after shoulder arthroscopy. With shoulder injuries, either acute traumatic event or repetitive stress, the integrity of the cartilage may become compromised due to several factors such as abnormal loading conditions and repeated stresses. Injuries to the glenohumeral articular cartilage can be visualized with MRI, which is the only modality for detailed non-invasive assessment of this joint space. Osteoarthritic changes to articular cartilage such as loss and breakdown of proteoglycan molecules has been quantified with high sensitivity with T1¿ MRI . Therefore, the aim of this study is to develop a T1¿ MRI protocol to accurately quantify biochemical properties of the glenohumeral articular cartilage to monitor the development of cartilage degeneration in vivo.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 盂肱关节炎是一种致残性疾病，可能严重影响生活质量和娱乐活动及日常生活。原发性盂肱关节炎主要发生在老年人中;然而，最近有一个年轻患者队列在肩关节镜检查后出现终末期盂肱关节炎。 对于肩关节损伤，无论是急性创伤事件还是重复应力，软骨的完整性可能会由于几个因素而受到损害，例如异常负荷条件和重复应力。 盂肱关节软骨的损伤可以通过MRI可视化，这是对该关节间隙进行详细非侵入性评估的唯一方式。 关节软骨的骨关节炎改变，如蛋白聚糖分子的丢失和分解，已经用T1 <$MRI高灵敏度定量。因此，本研究的目的是开发一种T1 <$MRI方案，以准确量化盂肱关节软骨的生化特性，从而监测体内软骨退化的发展。