Predicting Useful Speech in Children With Autism

描述（由申请人提供）：采用纵向相关设计，将解决9个目标。前三个目标是研究早期词汇发展的独特预测因素，以及父母输入在这个预测模型中可能发挥的潜在中介作用。在目标1中，我们测试是否存在增量（即，（a）早期儿童有意交流、注意力跟随和物体游戏，（B）早期儿童运动能力和（c）随时间变化的儿童词汇理解在预测交际词使用增长率方面的有效性。在目标2中，我们测试了（a）早期儿童有意沟通，注意力跟随和物体游戏，（B）对儿童指导言语的注意力，以及（B）父母变量在预测理解增长率方面是否具有增量效度。在目标3中，我们测试早期父母因素和儿童的交际词使用的增长之间的关联是否通过儿童的词汇理解的发展来介导。接下来的3个目标涉及测试纵向相关性，如果得到证实，与儿童对父母使用假定的促进行为的影响一致。在目标4中，我们测试了儿童早期的有意沟通频率和注意力是否能正向预测父母语言映射的后期频率。在目标5，我们测试是否儿童的早期对象发挥积极预测后来的父母同步非义务性谈话。在目标6，我们测试是否儿童的早期要求积极预测后来的父母倾向于使用响应策略。最后3个目标涉及根据图1所示模型的关键预测测试替代模型。在目标7中，我们测试早期父母变量和后来的理解之间的关联是否大于早期理解和后来的父母变量之间的关联。在目标8中，我们测试了早期理解和后期表达之间的关联是否大于早期表达和后期理解之间的关联。在目标9中，我们测试了早期注意儿童导向言语和后来的理解之间的关联是否大于早期理解和后来注意儿童导向言语之间的关联。将使用混合水平建模、多元回归和改良的Pearson-Filon统计量来检验目标。已申请五年资助。公共卫生相关性：自闭症的发病率现在估计为1：150出生。小学生的交际用语是年轻人与成年人的社会和就业结果的重复预测因子。预测在获取交际词使用的变化可能会识别前兆，是适当的早期治疗目标。

DESCRIPTION (provided by applicant): Using a longitudinal correlational design, nine aims will be addressed. The first three aims examine the unique predictors of early lexical development and the potential mediating role that parental input may play in this predictive model. In Aim 1, we test whether there is incremental (i.e., significant prediction above and beyond other predictors) validity of (a) early child intentional communication, attention following, and object play, (b) early child motor ability and (c) time-varying child vocabulary comprehension in predicting growth rate of communicative word use. In Aim 2, we test whether there is incremental validity of (a) early child intentional communication, attention following, and object play, (b) attention to child-directed speech, and (b) parental variables in predicting growth rate of comprehension. In Aim 3, we test whether the association between early parental factors and the child's growth of communicative word use is mediated through the child's development of vocabulary comprehension. The next 3 aims involve testing longitudinal correlations that, if confirmed, are consistent with child effects on parental use of putative facilitative behaviors. In Aim 4, we test whether children's early frequency of intentional communication and attention following positively predict later frequency of parental linguistic mapping. In Aim 5, we test whether children's early object play positively predicts later parental synchronous nonobligatory talk. In Aim 6, we test whether children's early requesting positively predicts later parental tendency to use responsive strategies. The final 3 aims involve testing alternative models against key predictions of the model presented in Figure 1. In Aim 7, we test whether the association between early parent variables and later comprehension is greater than the association between early comprehension and later parent variables. In Aim 8, we test whether the association between early comprehension and later expression is greater than the association between early expression and later comprehension. In Aim 9, we test whether the association between early attention to child directed speech and later comprehension is greater than the association between early comprehension and later attention to child-directed speech. Mixed level modeling, multiple regression, and the modified Pearson-Filon statistic will be used to test the aims. Five years of funding are requested. PUBLIC HEALTH RELEVANCE: The incidence of autism is now estimated to be 1:150 births. Communicative word use by elementary school is a replicated predictor of social and employment outcomes in young adults with adults. Predicting variance in acquiring communicative word use may identify precursors that are appropriate early treatment targets.