Development of infrared optical fibre devices and systems for applications in medical diagnosis.

开发用于医疗诊断的红外光纤器件和系统。

• 批准号: G0701869/1
• 负责人: Angela Seddon
• 金额: $ 12.45万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701869%2F1
• 关键词: Development; infrared; optical; fibre; devices

We aim to develop a mid-infrared fibreoptic device for use in surface tissue evaluation to help medical diagnosis and possible early detection of skin cancer. Skin cancers are the most common of all human cancers and their number is increasing annually. For skin diagnostics, the reference standard at present is visual inspection by an experienced dermatologist, but this is both time-consuming and dependent on human judgement. Mid-infrared light (invisible to the naked eye) potentially provides a clinically important diagnostic capability. The mid-infrared light reflected from tissue like skin is rich in characteristic tissue signatures. The light is amenable to the technique of spectroscopy i.e. monitoring of light intensity after interaction with the tissue. There are examples in the recent literature of spectroscopic differences between malignant and normal tissue in surgically removed tissue. Our challenge is to develop a device for carrying out tissue spectroscopy on skin in vivo. Such a device could lead to easier, faster, more accurate diagnoses and perhaps screening for skin cancer. A key enabling technology for practical deployment of this device is the means of efficiently routing the light to where it is needed. We are engineers working on a practical solution of a device based on mid-infrared-transmitting optical fibres to carry the light.

我们的目标是开发一种用于表面组织评估的中红外光纤设备，以帮助医学诊断和可能的皮肤癌早期检测。皮肤癌是人类所有癌症中最常见的，其数量每年都在增加。对于皮肤诊断，目前的参考标准是由经验丰富的皮肤科医生进行肉眼检查，但这既耗时又依赖于人的判断。中红外光(肉眼不可见)潜在地提供了一种重要的临床诊断能力。从皮肤等组织反射的中红外光具有丰富的组织特征。光适用于光谱学技术，即监测与组织相互作用后的光强度。在最近的文献中，有手术切除的组织中恶性组织和正常组织之间的光谱差异的例子。我们的挑战是开发一种在活体皮肤上进行组织光谱分析的设备。这样的设备可能会带来更容易、更快、更准确的诊断，或许还会筛查皮肤癌。该设备实际部署的一项关键技术是将光有效地路由到需要的地方。我们是工程师，致力于一种基于中红外传输光纤来传输光的设备的实用解决方案。