Novel Approaches for the Control of Microbial Pathogens

描述（由申请人提供）：五年的支持，要求建立一个教师发展计划，使初级教师参与研究在三个博士学位。授予堪萨斯的机构（劳伦斯的堪萨斯大学和堪萨斯城的堪萨斯大学医学院，以及堪萨斯州立大学）更有竞争力，以获得国家卫生研究院的资助，并招募能够开发新研究项目的高级教师。一个由Narayan博士和个人项目导师组成的强大的指导计划，他们都是既定的研究人员，一个旨在帮助COBRE成员准备手稿和赠款的写作计划，以及一个每年两次审查所有项目进展情况的外部咨询委员会将成立。五个核心，一个行政，一个专注于写作，三个技术，已经在目前的COBRE的最后一年建立，以加快新的研究计划。COBRE在三个技术核心中获得了广泛的新机构支持，包括全职员工和新的研究设备。研究主题集中在基础和翻译机制，旨在抑制病原微生物的复制。研究将集中在鉴定微生物基因和基因产物，这些基因和基因产物在其复制中具有开创性作用，并将其用作治疗靶点。COBRE的翻译部分将致力于使用纳米颗粒作为体内递送载体的基因治疗。COBRE的支持将用于支持四名初级教师和一名高级教师的三年期项目，用于加强三个机构新教师招聘计划的资金，以及用于进一步招聘高级教师的资金，这些教师可以为新研究计划的发展做出贡献。资金还将用于运行三个技术核心，包括最先进的流式细胞术、信号转导和Luminex技术，这将有助于快速分析感染后产生的宿主反应基因产物。目前选定的教师的项目是基于科学价值，外部咨询委员会成员的审查，重点是与其他项目的互补互动，发展成为由高级教师领导的新研究项目的潜力，以及获得NIH资助支持的可能性。其中两个技术核心将由两名教师指导，他们以前得到COBRE的支持，每人获得了两笔NIH赠款。新计划是为了响应新的RFA而开发的，该RFA建议招聘高级教师，他们可以帮助开发和领导新的研究项目。目前已经招聘了一名这样的高级教员。最后，新计划是基于我们的记录，其中11名研究人员由以前的COBRE支持，共获得16笔校外赠款。11人中有8人获得了12项NIH赠款。

DESCRIPTION (provided by applicant): Five years of support are requested to create a faculty development program that will enable junior faculty involved in research at the three Ph.D. granting institutions in Kansas (KU at Lawrence and the KU School of Medicine in Kansas City, and Kansas State University) to become more competitive for securing NIH grant support and to recruit senior faculty who could develop new research programs. A strong mentoring program comprised of Dr. Narayan and individual Project mentors, all of whom are established investigators, a writing program designed to assist COBRE members in preparation of manuscripts and grants, and an external advisory committee who will review progress of all Projects twice annually will be established. Five Cores, one administrative, one focused on writing, and three technical, have already been established in the final year of the present COBRE to expedite the new research program. The COBRE has received extensive new institutional support in the form of FTEs and new research equipment in the three technical Cores. The research theme is centered on basic and translational mechanisms aimed at inhibiting replication of pathogenic microbes. Studies will be focused on identification of microbial genes and gene products that have a seminal role in their replication and use of these as targets for therapy. The translational portion of the COBRE will be dedicated to use of gene therapy using nanoparticles as vectors for delivery in vivo. The COBRE support will be used to support three-year Projects of four junior faculty and one senior faculty, funds for enhancement of recruitment packages of new faculty at the three institutions, and funds for further recruitment of senior faculty who could contribute to development of new research programs. Funds will also be used to operate the three technical Cores comprised of state-of-the-art flow cytometry, signal transduction, and Luminex technology, which will facilitate rapid analysis of host response gene products resulting from infection. The Projects of currently selected faculty were based on scientific merit, review by External Advisory Committee members, with a focus for complementary interaction with other Projects, potential for development into new research programs headed by senior faculty, and likelihood for receiving NIH grant support. Two of the technical Cores will be directed by two faculty members who were previously supported by the COBRE and who have each secured two NIH grants. The new program was developed in response to the new RFA that suggested recruitment of senior faculty who could help develop and head new research programs. One such senior faculty has already been recruited. Finally, the new program has been based on our track record in which eleven investigators supported by the previous COBRE have secured a total of 16 extramural grants. Eight of the eleven have secured 12 NIH grants.