COBRE KS: FERMENTATION & SCREENING CORE

描述（由申请人提供）：要求五年的支持， 创建一个教师发展计划，使初级教师参与 在堪萨斯的三个博士授予机构（KU在劳伦斯 和堪萨斯城的KU医学院，以及K州立大学）， 在获得NIH资助方面更具竞争力。完成这项工作的方法是 通过创建一个强大的指导机构（由纳拉扬博士和其他人组成） 在这三个机构建立，NIH资助的高级教师）， 建立COBRE内部和外部顾问委员会 方案、每月研讨会制度化和数据介绍 会议和一次年度会议，专门讨论筹备工作中的重要因素 NIH拨款申请三个核心，一个行政，两个技术 将加快研究计划的实施。眼镜蛇将收到 以全职员工、新的研究设备、 和空间.本研究的主题是围绕抑制机制， 病原微生物的复制，长期目标是控制 传染病对人类健康很重要。研究将集中在 鉴定在以下方面具有开创性作用的基因和基因产物： 微生物复制为了找到这些蛋白质的抑制剂，我们将 与KU/Lawrence的COBRE计划合作， 化学和高通量筛选蛋白质的抑制剂， 问题我们还将利用核心支持开发更多的生物学方法 与噬菌体展示和适体技术，这将是共享之间 investigators.此外，我们将建立X射线的核心设施， 晶体学和发酵的分离和测定， 蛋白质的三维结构，这将有助于开发 潜在的毒品六名初级教员，其中两名经验丰富 X射线晶体学家，已被选为支持两到三个 年目前选定的教师的项目是基于科学的 优点，与其他项目互补互动的潜力，以及 开发COBRE计划核心资源的潜力。项目 新的初级教师将被选中，并根据推荐的奖项 内部咨询委员会。COBRE基金的一部分将用于 加强教师招聘包。

DESCRIPTION (provided by applicant): Five years of support are requested to create a faculty development program that will enable junior faculty involved in research at the three PhD granting institutions in Kansas, (KU at Lawrence and the KU School of Medicine in Kansas City, and K State University) to become more competitive for securing NIH grant support. This will be achieved by creation of a strong mentoring body (comprised of Dr. Narayan and other established, NIH-funded senior faculty at the three institutions), establishment of committees of internal and outside advisors to the COBRE program, institutionalization of monthly seminar and data presentation meetings, and an annual meeting dedicated to factors important in preparation of NIH grant applications. Three cores, one administrative, and two technical will be established to expedite the research program. The COBRE will receive extensive institutional support in the form of FTEs, new research equipment, and space. The research theme is centered on mechanisms inhibiting replication of pathogenic microbes, with the long-term goal of controlling infectious diseases important in human health. Studies will be focused on identification of genes and gene products that have a seminal role in microbial replication. To find inhibitors for these proteins, we will link up with the COBRE program at KU/Lawrence to exploit resources in combinatorial chemistry and high-throughput screens for inhibitors of the proteins in question. We will also exploit more biological approaches using core support with phage display and aptamer technology, which will be shared among investigators. Further, we will establish core facilities in X-ray crystallography and fermentation for the isolation and determination of the 3-D structures of the proteins, which will be useful for development of potential drugs. Six junior faculty members, two of whom are experienced X-ray crystallographers, have been selected for support for two to three years. The projects of currently selected faculty were based on scientific merit, potential for complementary interaction with other projects, and potential for exploiting the core resources of both COBRE programs. Projects of new junior faculty will be selected and awards made upon recommendation of the internal advisory committee. A portion of the COBRE fund will be used to enhance faculty recruitment packages.